Towards a Consensus on Alzheimer's Disease Comorbidity?
Towards a Consensus on Alzheimer's Disease Comorbidity?
复制标题
在阿尔茨海默病共病问题上达成共识？
DOI：
10.3390/jcm10194360
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发表时间：
2021-09-24
影响因子：
3.9
通讯作者：
Braitbard O
中科院分区：
文献类型：
--
作者：
Avitan I;Halperin Y;Saha T;Bloch N;Atrahimovich D;Polis B;Samson AO;Braitbard O
阿尔茨海默病(AD)通常与其他病理疾病并存。首先，我们简要回顾一下临床上与AD最相关的疾病。然后，我们使用400种常见病理学的列表，查询PubMed对AD与其他疾病共存的引用。值得注意的是，AD被发现与精神分裂症和精神病、睡眠失眠和呼吸暂停、2型糖尿病、动脉粥样硬化、高血压、心血管疾病、肥胖、纤颤、骨质疏松症、关节炎、青光眼、代谢综合征、疼痛、疱疹、艾滋病毒、酒精中毒、心力衰竭、偏头痛、肺炎、血脂异常、COPD和哮喘、听力损失和吸烟有关。微不足道的是，AD还被发现与几种神经退行性疾病有关，这些疾病被忽视了。值得注意的是，我们的预测结果与之前发表的临床数据一致，并与个别出版物有很好的相关性。我们的结果强调了危险因素，并传播了经常与AD相关的疾病。有趣的是，这些并存的疾病通常是被活性氧加剧的退行性疾病，因此强调了抗氧化剂在治疗AD和共病中的潜在作用。
Alzheimer’s disease (AD) is often comorbid with other pathologies. First, we review shortly the diseases most associated with AD in the clinic. Then we query PubMed citations for the co-occurrence of AD with other diseases, using a list of 400 common pathologies. Significantly, AD is found to be associated with schizophrenia and psychosis, sleep insomnia and apnea, type 2 diabetes, atherosclerosis, hypertension, cardiovascular diseases, obesity, fibrillation, osteoporosis, arthritis, glaucoma, metabolic syndrome, pain, herpes, HIV, alcoholism, heart failure, migraine, pneumonia, dyslipidemia, COPD and asthma, hearing loss, and tobacco smoking. Trivially, AD is also found to be associated with several neurodegenerative diseases, which are disregarded. Notably, our predicted results are consistent with the previously published clinical data and correlate nicely with individual publications. Our results emphasize risk factors and promulgate diseases often associated with AD. Interestingly, the comorbid diseases are often degenerative diseases exacerbated by reactive oxygen species, thus underlining the potential role of antioxidants in the treatment of AD and comorbid diseases.
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影响因子：
168.9
作者：
Ballard, Clive;Gauthier, Serge;Jones, Emma
通讯作者：
Jones, Emma
影响因子：
--
作者：
Atrahimovich D;Samson AO;Khattib A;Vaya J;Khatib S
通讯作者：
Khatib S
影响因子：
--
作者：
Atrahimovich D;Khatib S;Sela S;Vaya J;Samson AO
通讯作者：
Samson AO
影响因子：
2.1
作者：
Fonar, Gennadiy;Polis, Baruh;Samson, Abraham O.
通讯作者：
Samson, Abraham O.
影响因子：
4.2
作者：
Beydoun, May A.;Canas, J. Atilio;Zonderman, Alan B.
通讯作者：
Zonderman, Alan B.