Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet.
Punicalagin Decreases Serum Glucose Levels and Increases PON1 Activity and HDL Anti-Inflammatory Values in Balb/c Mice Fed a High-Fat Diet.
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DOI：
10.1155/2018/2673076
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发表时间：
2018
影响因子：
--
通讯作者：
Khatib S
中科院分区：
文献类型：
--
作者：
Atrahimovich D;Samson AO;Khattib A;Vaya J;Khatib S
人类日常饮食中摄入多酚类物质，多酚类物质可降低罹患多种慢性病的风险，包括癌症、心血管疾病和糖尿病。传统上，多酚的健康益处被归因于它们的抗氧化活性，但许多研究可能会受到口服给药和微不足道的生物利用度的阻碍。多酚表达其有益效果的机制似乎涉及它们与蛋白质的相互作用，而不是发挥直接的抗氧化作用。本研究旨在拓宽和证实我们最近发表的体外结果，即多酚可能通过与动脉粥样硬化相关的蛋白质和脂蛋白相互作用来降低动脉粥样硬化的风险。在体内检测了辣椒素和槲皮素与糖脂水平、对氧磷酶1(PON1)活性和炎症相关的生物学功能。小鼠被喂以高脂饮食(HFD)12周，在最后4周，它们通过植入微泵接受皮下治疗，这种微泵每天向血清中释放生理浓度的Punicalagin、Qercetin或阿托伐他汀(作为阳性对照)。HFD降低了血清PON1活性，而给予Popicalagin使PON1活性恢复到正常饮食小鼠的水平。此外，Punicalagin显著降低了HFD小鼠的血糖水平，并改善了高密度脂蛋白的抗炎特性。总而言之，除了抗氧化活性，多酚发挥其有益特性的机制似乎涉及它们与血清蛋白质的相互作用，这些蛋白质介导了高密度脂蛋白的功能和血液循环中的脂肪-葡萄糖状态。
Polyphenols are consumed daily in the human diet and are associated with reduced risk of a number of chronic diseases, including cancer, cardiovascular disease, and diabetes. Traditionally, the health benefits of polyphenols have been attributed to their antioxidant activity, but many studies might be hampered by oral administration and insignificant bioavailability. Rather than exerting a direct antioxidant effect, the mechanisms by which polyphenols express their beneficial effect seem to involve their interaction with proteins. The present study is aimed at broadening and confirming our recently published in vitro results showing that polyphenols may reduce atherosclerosis risk via interaction with proteins and lipoproteins related to atherosclerosis. The biological functions of punicalagin and quercetin in relation to glucose and lipid levels, paraoxonase 1 (PON1) activity, and inflammation were examined in vivo. Mice were fed a high-fat diet (HFD) for 12 weeks, and during the last 4 weeks, they received subcutaneous treatments via implanted minipumps, which released physiological concentrations of punicalagin, quercetin, or atorvastatin (as a positive control) daily into the serum. The HFD reduced serum PON1 activity, whereas punicalagin administration restored PON1 activity to the level of mice fed a normal diet. In addition, punicalagin significantly reduced glucose levels in HFD mice and improved HDL anti-inflammatory properties. In conclusion, beyond antioxidant activity, the mechanisms by which polyphenols exert their beneficial properties appear to involve their interaction with serum proteins that mediate HDL function and lipid-glucose state in the circulation.
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影响因子：
2.1
作者：
Gur, Mustafa;Cayli, Murat;Aksoy, Nurten
通讯作者：
Aksoy, Nurten
关于胃肠道中石榴的抗炎活性的综述。
DOI：
10.1155/2013/247145
发表时间：
2013
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
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通讯作者：
Dell'agli M
影响因子：
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通讯作者：
Marette, Andre
DOI：
10.1161/atvbaha.113.301468
发表时间：
2013-12-01
影响因子：
8.7
作者：
Camont, Laurent;Lhomme, Marie;Kontush, Anatol
通讯作者：
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影响因子：
6.1
作者：
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