Cardiometabolic Complications in Youth With Perinatally Acquired HIV in the Era of Antiretroviral Therapy.
Cardiometabolic Complications in Youth With Perinatally Acquired HIV in the Era of Antiretroviral Therapy.
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DOI：
10.1007/s11904-021-00574-x
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发表时间：
2021-10
影响因子：
4.6
通讯作者：
McComsey GA
中科院分区：
文献类型：
--
作者：
Dirajlal-Fargo S;McComsey GA
抗逆转录病毒疗法（ART）的推广大大降低了儿童艾滋病毒的死亡率和发病率。目前，预计感染围产期艾滋病毒的儿童将度过青春期并进入成年期，因此，青少年现在是感染艾滋病毒的最大增长群体。本综述旨在讨论在新的抗逆转录病毒治疗方案中心脏代谢共病的患病率和机制，以及仍然存在的研究空白。数据突出显示，在较新的ART的设置中，PHIV亚临床心脏代谢并发症的持续风险。成像和组学的新技术可能有助于识别这个年轻人群的早期心脏代谢异常，并可能识别与这些变化相关的机械途径的早期变化。进一步的研究，以确定风险和管理策略的心脏代谢的影响，在PHIV青少年，超越艺术，是必要的。重点应放在预防这些并发症的青年，以避免新的流行病的糖尿病和心血管疾病时，这些青年成为老年人。
Antiretroviral therapy (ART) scale-up has dramatically reduced rates of pediatric HIV mortality and morbidity. Children living with perinatally acquired HIV (PHIV) are now expected to live through adolescence and well into adulthood, such that adolescents now represent the largest growing population living with HIV. This review aims to discuss the prevalence and mechanisms for cardiometabolic co-morbidities in the setting of newer ART regimens and the research gaps that remain. Data highlight the continued risks of subclinical cardiometabolic complications in PHIV in the setting of newer ART. Novel techniques in imaging and omics may help identify early cardiometabolic abnormalities in this young population and potentially identify early changes in the mechanistic pathways related to these changes. Further studies to determine risk and management strategies of the cardiometabolic effects in PHIV adolescents, beyond ART, are warranted. Focus should be on prevention of these complications in youth to avoid new epidemic of diabetes and cardiovascular disease when these youth become aging adults.
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影响因子：
3.7
作者：
Cames C;Pascal L;Ba A;Mbodj H;Ouattara B;Diallo NF;Msellati P;Mbaye N;Sy Signate H;Blanche S;Diack A;MAGGSEN Cohort Study Group
通讯作者：
MAGGSEN Cohort Study Group
影响因子：
3.7
作者：
Crum-Cianflone N;Roediger MP;Eberly L;Headd M;Marconi V;Ganesan A;Weintrob A;Barthel RV;Fraser S;Agan BK;Infectious Disease Clinical Research Program HIV Working Group
通讯作者：
Infectious Disease Clinical Research Program HIV Working Group
影响因子：
29.4
作者：
Bouter, Kristien E.;van Raalte, Daniel H.;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max
影响因子：
3
作者：
Dirajlal-Fargo, S.;Shan, L.;McComsey, G. A.
通讯作者：
McComsey, G. A.
DOI：
10.1097/qad.0000000000000376
发表时间：
2014-09-10
期刊：
AIDS (London, England)
影响因子：
--
作者：
Chanthong P;Lapphra K;Saihongthong S;Sricharoenchai S;Wittawatmongkol O;Phongsamart W;Rungmaitree S;Kongstan N;Chokephaibulkit K
通讯作者：
Chokephaibulkit K