Relapse-related molecular signature in early-stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor-infiltrating lymphocytes.
Relapse-related molecular signature in early-stage lung adenocarcinomas based on base excision repair, stimulator of interferon genes pathway and tumor-infiltrating lymphocytes.
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基于碱基切除修复、干扰素基因通路刺激剂和肿瘤浸润淋巴细胞的早期肺腺癌复发相关分子特征。
DOI：
10.1111/cas.14570
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发表时间：
2020-10
期刊：
影响因子：
5.7
通讯作者：
Wang D
中科院分区：
文献类型：
--
作者：
Yang B;Rao W;Luo H;Zhang L;Wang D
约30%的早期非小细胞肺癌（NSCLC）患者在术后5年内复发。因此，有必要确定早期NSCLC的稳健和可靠的预后特征。对147例I期肺腺癌（I-LUAD期）患者的免疫组化数据进行分析，以了解碱基切除修复（BER）、干扰素基因刺激因子（STING）和肿瘤浸润淋巴细胞（TIL）的蛋白表达，以探讨蛋白表达与预后的关系。通过诺模图进一步建立预测模型，并使用The Cancer Genome Atlas和Gene Expression Omnibus（GEO）数据库进行外部验证。XRCC 1和H2 AX是无复发生存期（RFS）的阴性预后标志物，而CD 8、CD 20和STING是RFS的阳性预后标志物。RFS的列线图共享共同的预后标志物，包括XRCC 1、H2 AX、STING、CD 8和CD 20。训练队列和内部验证队列的c指数分别为0.724和0.698。经外部验证，诺模图模型对I-LUAD期复发具有良好的预测。相关分析显示APE 1和H2 AX与STING呈负相关，STING与TIL呈正相关。BER、STING途径和TIL与早期复发相关，并与I-LUAD期的组织表达相关。我们的列线图模型是I-LUAD期复发的良好预测因子。在本研究中，BER、STING通路和TIL与早期复发相关，并与I-LUAD期的组织表达相关。
Approximately 30% of patients with early‐stage non–small cell lung cancer (NSCLC) relapse within 5 years after surgery. Therefore, it is necessary to identify a robust and reliable prognostic signature for early‐stage NSCLC. Immunohistochemistry data from 147 patients with stage I lung adenocarcinoma (stage I‐LUAD) were analyzed for the protein expression of base excision repair (BER), stimulator of interferon genes (STING) and tumor‐infiltrating lymphocytes (TIL) to explore the relationship between protein expression and prognosis. A prediction model was further established by nomogram and externally verified using The Cancer Genome Atlas and Gene Expression Omnibus (GEO) databases. XRCC1 and H2AX are negative prognostic markers for relapse‐free survival (RFS), while CD8, CD20 and STING are positive prognostic markers for RFS. Nomograms for RFS share common prognostic markers, including XRCC1, H2AX, STING, CD8 and CD20. The c‐index was 0.724 and 0.698 in the training cohort and the internal validation cohort, respectively. It was externally verified that the nomogram model had a good prediction for recurrence of stage I‐LUAD. Correlation analysis showed that APE1 and H2AX were negatively correlated with STING, while STING was positively correlated with TIL. BER, the STING pathway and TIL were associated with early recurrence and were correlated with the tissue expression of stage I‐LUAD. Our nomogram model was a good predictor for recurrence of stage I‐LUAD. In the present study, BER, the STING pathway and TIL were associated with early recurrence and correlated with the tissue expression of stage I‐LUAD.
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影响因子：
28.2
作者：
Mouw KW;Goldberg MS;Konstantinopoulos PA;D'Andrea AD
通讯作者：
D'Andrea AD
影响因子：
4.7
作者：
Lu, Yan;Govindan, Ramaswamy;You, Ming
通讯作者：
You, Ming
影响因子：
158.5
作者：
Brock, Malcolm V.;Hooker, Craig M.;Herman, James G.
通讯作者：
Herman, James G.
影响因子：
7.3
作者：
Galon, Jerome;Mlecnik, Bernhard;Bindea, Gabriela;Angell, Helen K.;Berger, Anne;Lagorce, Christine;Lugli, Alessandro;Zlobec, Inti;Hartmann, Arndt;Bifulco, Carlo;Nagtegaal, Iris D.;Palmqvist, Richard;Masucci, Giuseppe V.;Botti, Gerardo;Tatangelo, Fabiana;Delrio, Paolo;Maio, Michele;Laghi, Luigi;Grizzi, Fabio;Asslaber, Martin;D'Arrigo, Corrado;Vidal-Vanaclocha, Fernando;Zavadova, Eva;Chouchane, Lotfi;Ohashi, Pamela S.;Hafezi-Bakhtiari, Sara;Wouters, Bradly G.;Roehrl, Michael;Nguyen, Linh;Kawakami, Yutaka;Hazama, Shoichi;Okuno, Kiyotaka;Ogino, Shuji;Gibbs, Peter;Waring, Paul;Sato, Noriyuki;Torigoe, Toshihiko;Itoh, Kyogo;Patel, Prabhu S.;Shukla, Shilin N.;Wang, Yili;Kopetz, Scott;Sinicrope, Frank A.;Scripcariu, Viorel;Ascierto, Paolo A.;Marincola, Francesco M.;Fox, Bernard A.;Pages, Franck
通讯作者：
Pages, Franck
依赖于STING的胞质DNA感应促进了辐射诱导的I型干扰素依赖性抗肿瘤免疫。
影响因子：
32.4
作者：
Deng, Liufu;Liang, Hua;Xu, Meng;Yang, Xuanming;Burnette, Byron;Arina, Ainhoa;Li, Xiao-Dong;Mauceri, Helena;Beckett, Michael;Darga, Thomas;Huang, Xiaona;Gajewski, Thomas F.;Chen, Zhijian J.;Fu, Yang-Xin;Weichselbaum, Ralph R.
通讯作者：
Weichselbaum, Ralph R.