Assessment of multiple task activation and reproducibility in patients with benign and low-grade neoplasm.

Assessment of multiple task activation and reproducibility in patients with benign and low-grade neoplasm.
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DOI:
10.1177/153303461000900402
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发表时间:
2010-08
影响因子:
2.8
通讯作者:
Tomé WA
Tomé WA
中科院分区:
医学4区
文献类型:
--
作者:
McKinsey RD;Moritz CH;Meyerand ME;Tomé WA

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24例良性和低级别脑肿瘤患者分别进行了两次迭代的四种功能磁共振成像范式:语言(单词生成),主要和关联听觉(文本听力),上肢精细运动控制(交替肢体双侧手指敲击),和主要视觉感知(反转棋盘)。对于每次扫描,生成具有不同阈值的激活簇,并用于计算再现性参数:质心(COM)位置差异、Rsize和Roverlap。所有任务的COM、Rsize和Roverlap值的平均差异范围分别为1.70±0.53 mm - 10.60±3.21 mm、0.6±0.04 - 0.90±0.05和0.23±0.12 - 1±0.16。这些值的范围内,或高于,以前发表的报告功能磁共振成像重测精度。功能磁共振成像是一种非侵入性的工具,具有可接受的再现性措施,用于评估计划接受放射治疗的患者的多语言和感觉运动功能的定位。
Twenty-four patients with proven benign and low-grade brain neoplasms each performed two iterations of four fMRI paradigms: language (word generation), primary and association auditory (text listening), upper limb fine motor control (alternating-limb bilateral finger tapping), and primary visual perception (reversing checkerboard). Activation clusters with varying thresholds were generated for each scan and used to calculate reproducibility parameters: Difference in the Center of Mass (COM) location, Rsize, and Roverlap. The average difference in the COM, Rsize, and Roverlap values ranged from 1.70±0.53 mm – 10.60±3.21 mm, 0.6±0.04 – 0.90±0.05 and 0.23±0.12 – 1±0.16 respectively for all tasks. These values are within the range of, or higher than, previously published reports on fMRI test-retest precision. FMRI is indicated to be a noninvasive tool with acceptable reproducibility measures for assessing the localizations of multiple language and sensorimotor functions in patients scheduled for radiotherapy treatment.
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