Can Exercise Ameliorate Aromatase Inhibitor-Induced Cognitive Decline in Breast Cancer Patients?
Can Exercise Ameliorate Aromatase Inhibitor-Induced Cognitive Decline in Breast Cancer Patients?
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DOI：
10.1007/s12035-015-9341-9
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发表时间：
2016-08
影响因子：
5.1
通讯作者：
Li R
中科院分区：
文献类型：
--
作者：
Li C;Zhou C;Li R
芳香化酶抑制剂（AIs）是乳腺癌的一种有效的辅助治疗药物，尤其适用于雌激素受体阳性的绝经期妇女。由于芳香酶的性质，内源性雌激素合成的关键酶，抑制芳香酶诱导的副作用，如认知障碍，已在人类和动物研究中报道。虽然大量证据表明体育锻炼可以改善学习和记忆活动，甚至可以预防与年龄相关的认知能力下降，但基础研究揭示了运动和影响认知功能的雌激素信号之间的一些共同途径。本文结合临床和基础研究，探讨运动对乳腺癌人工免疫治疗女性认知功能的潜在影响，并探讨运动对雌激素相关认知功能的影响及其机制。
Aromatase inhibitors (AIs) have been commonly used as an effective adjuvant therapy in treatment of breast cancer, especially for menopausal women with estrogen receptor positive breast cancer. Due to the nature of aromatase, the key enzyme for endogenous estrogen synthesis, inhibitory of aromatase-induced side effects, such as cognitive impairment has been reported in both human and animal studies. While extensive evidences suggested that physical exercises can improve learning and memory activity and even prevent age-related cognitive decline, basic research revealed some common pathways between exercise and estrogen signaling that affected cognitive function. This review draws on clinical and basic studies to assess the potential impact of exercise in cognitive function from women treated with AIs for breast cancer and explore the potential mechanism and effects of exercise on estrogen-related cognition.
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影响因子：
3.4
作者：
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通讯作者：
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影响因子：
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