Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review
Transient Receptor Potential Channels and Chronic Airway Inflammatory Diseases: A Comprehensive Review
复制标题
瞬时受体电位通道与慢性气道炎症性疾病：综合综述
作者：
Yang Xia;Lexin Xia;Lingyun Lou;Rui Jin;Huahao Shen;Wen Li
慢性气道炎性疾病仍然是世界范围内的主要问题，因此需要额外的治疗靶点和新型药物。瞬时受体电位（TRP）通道是一组在全身表达的非选择性阳离子通道，受各种刺激调节。TRP通道已经在呼吸道的许多细胞类型中被鉴定，包括感觉神经元、气道上皮细胞、气道平滑肌细胞和成纤维细胞。不同类型的TRP通道通过迷走神经在感觉神经元中诱导咳嗽。气道上皮细胞中的TRP通道也调节渗透性和细胞因子的产生，并且这些通道也有助于支气管收缩的调节。TRP通道可能与其他TRP通道协同作用，或与钙依赖性钾通道和钙激活氯通道协同作用。因此，TRP通道可能是慢性气道炎症性疾病的潜在治疗靶点。本文就TRP通道在气道中的表达、生理功能及其在慢性气道炎症中的作用作一综述。
Chronic airway inflammatory diseases remain a major problem worldwide, such that there is a need for additional therapeutic targets and novel drugs. Transient receptor potential (TRP) channels are a group of non-selective cation channels expressed throughout the body that are regulated by various stimuli. TRP channels have been identified in numerous cell types in the respiratory tract, including sensory neurons, airway epithelial cells, airway smooth muscle cells, and fibroblasts. Different types of TRP channels induce cough in sensory neurons via the vagus nerve. Permeability and cytokine production are also regulated by TRP channels in airway epithelial cells, and these channels also contribute to the modulation of bronchoconstriction. TRP channels may cooperate with other TRP channels, or act in concert with calcium-dependent potassium channels and calcium-activated chloride channel. Hence, TRP channels could be the potential therapeutic targets for chronic airway inflammatory diseases. In this review, we aim to discuss the expression profiles and physiological functions of TRP channels in the airway, and the roles they play in chronic airway inflammatory diseases.
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