Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials.
Cholinergic pairing with visual activation results in long-term enhancement of visual evoked potentials.
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DOI：
10.1371/journal.pone.0005995
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发表时间：
2009-06-22
期刊：
影响因子：
3.7
通讯作者：
Vaucher E
中科院分区：
文献类型：
--
作者：
Kang JI;Vaucher E
乙酰胆碱(ACh)通过调节皮层的可塑性来调节神经元的活动强度和皮层神经元的选择性，从而参与学习过程。然而，ACh是否在初级视觉皮质(V1)引起维持视觉学习机制的长期效应尚不清楚。在本研究中，我们分析了视觉刺激与皮质内注射ACh类似物卡巴胆碱或刺激基底前脑后4-8h内大鼠V1区的视觉诱发电位(VEP)。为了阐明ACh对V1区视觉诱发电位活动的影响，我们在注射氨基甲胆碱之前，分别预先注射毒扁豆碱(东莨菪碱)、烟碱(甲氨基甲胺)、α7(甲基琥珀酸乌头碱)和N甲基丙二醛(CPP)受体拮抗剂。胆碱能系统的刺激与视觉刺激相结合，在6h内显著增加了VEP幅度(56%)。预先给予东莨菪碱、甲基苯丙胺和环丙沙星可完全消除这种长期增强作用，而抑制α7则可引起视觉诱发电位波幅的即刻增加。这表明ACh通过与LTP类似的机制促进视觉刺激的反应，LTP涉及NMDA在视觉皮质中传递的烟碱受体和M受体的相互作用。
Acetylcholine (ACh) contributes to learning processes by modulating cortical plasticity in terms of intensity of neuronal activity and selectivity properties of cortical neurons. However, it is not known if ACh induces long term effects within the primary visual cortex (V1) that could sustain visual learning mechanisms. In the present study we analyzed visual evoked potentials (VEPs) in V1 of rats during a 4–8 h period after coupling visual stimulation to an intracortical injection of ACh analog carbachol or stimulation of basal forebrain. To clarify the action of ACh on VEP activity in V1, we individually pre-injected muscarinic (scopolamine), nicotinic (mecamylamine), α7 (methyllycaconitine), and NMDA (CPP) receptor antagonists before carbachol infusion. Stimulation of the cholinergic system paired with visual stimulation significantly increased VEP amplitude (56%) during a 6 h period. Pre-treatment with scopolamine, mecamylamine and CPP completely abolished this long-term enhancement, while α7 inhibition induced an instant increase of VEP amplitude. This suggests a role of ACh in facilitating visual stimuli responsiveness through mechanisms comparable to LTP which involve nicotinic and muscarinic receptors with an interaction of NMDA transmission in the visual cortex.
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影响因子：
64.8
作者：
Herrero, J. L.;Roberts, M. J.;Delicato, L. S.;Gieselmann, M. A.;Dayan, P.;Thiele, A.
通讯作者：
Thiele, A.
影响因子：
2.5
作者：
Christophe, E;Roebuck, A;Audinat, E
通讯作者：
Audinat, E
影响因子：
1.7
作者：
Clapp, WC;Eckert, MJ;Abraham, WC
通讯作者：
Abraham, WC
影响因子：
3.3
作者：
Dotigny, F.;Ben Amor, A. Y.;Vaucher, E.
通讯作者：
Vaucher, E.
影响因子：
5.3
作者：
Ge, SY;Dani, JA
通讯作者：
Dani, JA