Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia.
Preleukemic Hematopoietic Stem Cells in Human Acute Myeloid Leukemia.
复制标题
DOI：
10.3389/fonc.2017.00263
复制
发表时间：
2017
影响因子：
4.7
通讯作者：
Majeti R
中科院分区：
文献类型：
--
作者：
Corces MR;Chang HY;Majeti R
急性髓性白血病（AML）是一种侵袭性骨髓恶性肿瘤，其特征是未分化的髓系细胞不受控制地增殖。数十年的研究表明，AML是从造血细胞单一谱系内连续获得遗传改变而演变而来的。最近，高通量测序的出现使得能够鉴定称为白血病前期的AML的恶化前阶段。多项研究表明，AML可由造血干细胞（HSC）内突变的积累引起。这些HSC被称为“白血病前HSC”，因为它们代表白血病的进化祖先。通过对这些白血病前期造血干细胞的生物学和临床特征的研究，本文旨在阐明该领域中一些尚未探索的问题。我们注意到，所讨论的一些材料是推测性的，提出这些材料是为了推动今后的工作。
Acute myeloid leukemia (AML) is an aggressive malignancy of the bone marrow characterized by an uncontrolled proliferation of undifferentiated myeloid lineage cells. Decades of research have demonstrated that AML evolves from the sequential acquisition of genetic alterations within a single lineage of hematopoietic cells. More recently, the advent of high-throughput sequencing has enabled the identification of a premalignant phase of AML termed preleukemia. Multiple studies have demonstrated that AML can arise from the accumulation of mutations within hematopoietic stem cells (HSCs). These HSCs have been termed “preleukemic HSCs” as they represent the evolutionary ancestors of the leukemia. Through examination of the biological and clinical characteristics of these preleukemic HSCs, this review aims to shed light on some of the unexplored questions in the field. We note that some of the material discussed is speculative in nature and is presented in order to motivate future work.
登录
查看更多内容
影响因子：
30.8
作者：
Busque L;Patel JP;Figueroa ME;Vasanthakumar A;Provost S;Hamilou Z;Mollica L;Li J;Viale A;Heguy A;Hassimi M;Socci N;Bhatt PK;Gonen M;Mason CE;Melnick A;Godley LA;Brennan CW;Abdel-Wahab O;Levine RL
通讯作者：
Levine RL
DOI：
10.1056/nejmoa1409405
发表时间：
2014-12-25
期刊：
The New England journal of medicine
影响因子：
--
作者：
Genovese G;Kähler AK;Handsaker RE;Lindberg J;Rose SA;Bakhoum SF;Chambert K;Mick E;Neale BM;Fromer M;Purcell SM;Svantesson O;Landén M;Höglund M;Lehmann S;Gabriel SB;Moran JL;Lander ES;Sullivan PF;Sklar P;Grönberg H;Hultman CM;McCarroll SA
通讯作者：
McCarroll SA
DOI：
10.1084/jem.20111490
发表时间：
2011-12-19
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dykstra B;Olthof S;Schreuder J;Ritsema M;de Haan G
通讯作者：
de Haan G
影响因子：
30.8
作者：
Corces, M. Ryan;Buenrostro, Jason D.;Wu, Beijing;Greenside, Peyton G.;Chan, Steven M.;Koenig, Julie L.;Snyder, Michael P.;Pritchard, Jonathan K.;Kundaje, Anshul;Gkeenleaf, William J.;Majeti, Ravindra;Chang, Howard Y.
通讯作者：
Chang, Howard Y.
影响因子：
20.3
作者：
Buscarlet, Manuel;Provost, Sylvie;Busque, Lambert
通讯作者：
Busque, Lambert