The microbiome, immunity, and schizophrenia and bipolar disorder.
The microbiome, immunity, and schizophrenia and bipolar disorder.
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DOI：
10.1016/j.bbi.2016.12.010
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发表时间：
2017-05
期刊：
影响因子：
--
通讯作者：
Yolken R
中科院分区：
文献类型：
--
作者：
Dickerson F;Severance E;Yolken R
精神分裂症和双相情感障碍是严重的神经精神障碍，病因不明。最近的研究表明，免疫激活可能有助于这些疾病的发病机制。在动物模型中的许多研究表明，粘膜微生物组可能通过改变免疫系统的功能来影响认知和行为。因此，微生物组可能在人类精神疾病中发挥作用。对精神分裂症和双相情感障碍的免疫改变和微生物组的研究尚处于起步阶段。最近两项关于精神分裂症患者口咽部微生物群的研究发现，病例组和对照组之间存在差异。其他研究发现，基于微生物易位的测量，精神分裂症和双相情感障碍的胃肠道炎症增加。一些研究还发现，抗生素的使用与精神疾病发病率的增加之间存在关联，这可能是由于微生物组的改变。表征患有这些疾病的个体的肠道微生物组的研究正在进行中。微生物组和免疫介导的病理学在精神分裂症和双相情感障碍中的作用的最终测试将来自改变肠道微生物群或胃肠道炎症的治疗剂的临床试验。这种模式的成功发展将代表一种新的战略，以预防和治疗严重的精神疾病。
Schizophrenia and bipolar disorder are serious neuropsychiatric disorders of uncertain etiology. Recent studies indicate that immune activation may contribute to the etiopathogenesis of these disorders. Numerous studies in animal models indicate that the mucosal microbiome may influence cognition and behavior by altering the functioning of the immune system. It is thus likely that the microbiome plays a role in human psychiatric disorders. The study of immune alterations and the microbiome in schizophrenia and bipolar disorder is in its infancy. Two recent investigations of the oro-pharyngeal microbiota in schizophrenia found differences between cases and controls. Other studies have found increased gastrointestinal inflammation in schizophrenia and bipolar disorder based on measures of microbial translocation. Several studies have also found an association between the receipt of antibiotics and an increased incidence of psychiatric disorders, perhaps due to alterations in the microbiome. Studies to characterize the intestinal microbiome of individuals with these disorders are in progress. The ultimate test of the role of the microbiome and immune-mediated pathology in schizophrenia and bipolar disorder will come from clinical trials of therapeutic agents which alter gut microbiota or gastrointestinal inflammation. The successful development of such modalities would represent a novel strategy to prevent and treat serious psychiatric disorders.
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影响因子：
11.1
作者：
Bahr SM;Weidemann BJ;Castro AN;Walsh JW;deLeon O;Burnett CM;Pearson NA;Murry DJ;Grobe JL;Kirby JR
通讯作者：
Kirby JR
影响因子：
2.7
作者：
Castro-Nallar E;Bendall ML;Pérez-Losada M;Sabuncyan S;Severance EG;Dickerson FB;Schroeder JR;Yolken RH;Crandall KA
通讯作者：
Crandall KA
影响因子：
5.4
作者：
Dickerson, Faith;Stallings, Cassie;Yolken, Robert
通讯作者：
Yolken, Robert
影响因子：
4.3
作者：
Desplat-Jego, S.;Escande, A.;Humbel, R. L.
通讯作者：
Humbel, R. L.
DOI：
10.1016/j.pnpbp.2012.06.019
发表时间：
2013-04-05
影响因子：
5.6
作者：
Bechter, K.
通讯作者：
Bechter, K.