Secondary Analysis of a Randomized Clinical Trial of Naltrexone Among Women Living With HIV: Correlations Between Reductions in Self-Reported Alcohol Use and Changes in Phosphatidylethanol.
Secondary Analysis of a Randomized Clinical Trial of Naltrexone Among Women Living With HIV: Correlations Between Reductions in Self-Reported Alcohol Use and Changes in Phosphatidylethanol.
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DOI：
10.1111/acer.14515
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发表时间：
2021-01
期刊：
影响因子：
--
通讯作者：
Cook RL
中科院分区：
文献类型：
--
作者：
Richards VL;Sajdeya R;Villalba K;Wang Y;Bryant V;Brumback B;Bryant K;Hahn JA;Cook RL
磷脂酰乙醇 (PEth) 等直接生物标志物能够检测大量饮酒，但尚不清楚自我报告的饮酒减少与 PEth 减少的相关性有多大。我们试图探索参与减少大量饮酒临床试验的艾滋病毒感染者 (WLWH) 女性样本中自我报告的饮酒量减少与 PEth 变化之间的相关性强度。我们还试图确定这种相关性在体重指数 (BMI) 较低的女性和没有酒精使用障碍 (AUD) 的女性中是否更强。 81 名 WLWH（平均年龄=48.7 岁，80% 黑人）参加了一项纳曲酮与安慰剂的随机试验，基线 PEth 呈阳性（≥8 ng/ml），基线、两个月和七个月的饮酒数据也纳入本次分析。通过比较斯皮尔曼相关系数，通过人口、生物和酒精使用因素来衡量基线 PEth 与每周饮酒次数之间的相关性。使用小型国际神经精神访谈来筛查 AUD。进一步分析按 BMI 和 AUD 进行分层。计算七个月内 PEth 变化和每周饮酒次数变化的 Spearman 相关系数，包括三个时间点：基线、2 个月和 7 个月。在基线时，与体重指数 (BMI) > 25 的患者相比，体重指数 (BMI) ≤ 25 的患者的基线 PEth 与每周饮酒次数之间的相关性显着更强（分别为 r=0.66；r=0.26）。同样，未筛查出 AUD 阳性的人与筛查出 AUD 的人相比，基线 PEth 与饮酒次数之间的相关性更强（分别为 r=0.66；r=0.25）。当按 BMI 分层时，BMI>25 的人存在低至中度相关性（r=0.32，p=0.02）；当按 AUD 进行分层时，仅在 0-2 个月内没有 AUD 的人中存在中等相关性 (r=0.50，p<.01)。在 WLWH 样本中，BMI 和 AUD 影响 PEth 与每周饮酒量之间的相关强度。未来需要研究更广泛人群中 PEth 随时间的变化，特别是了解性别差异导致的 PEth 差异。
Direct biomarkers such as phosphatidylethanol (PEth) have the capability to detect heavy alcohol use, but it is unclear how strongly self-reported reduction in alcohol use correlates with reduction in PEth. We sought to explore the strength of correlation between reductions in self-reported alcohol use and change in PEth among a sample of women living with HIV (WLWH) who participated in a clinical trial to reduce heavy alcohol use. We also sought to determine whether this correlation was stronger in women with lower body mass index (BMI) and women without an alcohol use disorder (AUD). 81 WLWH (mean age=48.7, 80% Black) engaging in a randomized trial of naltrexone versus placebo with a positive baseline PEth (≥8 ng/ml) and alcohol use data at baseline, two and seven months were included in this analysis. Spearman correlation coefficients were compared to measure the correlation between baseline PEth and number of drinks per week by demographic, biological, and alcohol use factors. Mini-International Neuropsychiatric Interview was used to screen for AUD. Further analyses were stratified by BMI and AUD. Spearman correlation coefficients were calculated for the change in PEth and the change in number of drinks per week over seven months, including three time-points: baseline, 2-months, and 7-months. At baseline, the correlation between baseline PEth and the number of drinks per week was significantly stronger for those with a body mass index (BMI) ≤25 compared to those with a BMI>25 (r=0.66; r=0.26, respectively). Similarly, the correlation between baseline PEth and number of drinks was stronger for those who did not screen positive for AUD compared to those who did (r=0.66; r=0.25, respectively). When stratifying by BMI, a low-to-moderate correlation (r=0.32, p=0.02) was present for persons with a BMI>25; when stratifying by AUD, a moderate correlation (r=0.50, p<.01) was present for persons without an AUD between 0-2 months only. In this sample of WLWH, BMI and AUD affected the strength of correlation between PEth and drinks per week. Future work examining changes in PEth over time in broader populations is needed, particularly to understand the differences in PEth due to sex differences.
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DOI：
10.1097/qai.0000000000001588
发表时间：
2018-02-01
影响因子：
3.6
作者：
Eyawo, Oghenowede;McGinnis, Kathleen A.;Tate, Janet P.
通讯作者：
Tate, Janet P.
影响因子：
2.2
作者：
Hoiseth, Gudrun;Bernard, Jean Paul;Morland, Jorg
通讯作者：
Morland, Jorg
在大型多种族基因组的关联研究中，饮酒差异的遗传因素因种族/种族而异。
影响因子：
11
作者：
Jorgenson E;Thai KK;Hoffmann TJ;Sakoda LC;Kvale MN;Banda Y;Schaefer C;Risch N;Mertens J;Weisner C;Choquet H
通讯作者：
Choquet H
影响因子：
3.2
作者：
Cook, Robert L.;Zhou, Zhi;Bryant, Kendall
通讯作者：
Bryant, Kendall
影响因子：
3.3
作者：
Rehm J;Probst C;Shield KD;Shuper PA
通讯作者：
Shuper PA