Magnetic barcoded hydrogel microparticles for multiplexed detection.
Magnetic barcoded hydrogel microparticles for multiplexed detection.
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DOI：
10.1021/la904903g
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发表时间：
2010-06-01
期刊：
影响因子：
--
通讯作者：
Doyle PS
中科院分区：
文献类型：
--
作者：
Bong KW;Chapin SC;Doyle PS
磁性聚合物颗粒已用于从靶向和分离到诊断和成像的各种应用中。目前的合成方法将这些颗粒限制为球形或球形形态的变形。在本文中，我们报告了使用停止流光刻生产磁性水凝胶微粒的图形代码区，探针区，和磁尾区。这些各向异性的多功能磁性聚合物颗粒是先前合成的“条形码”颗粒的增强版本[参考文献]，开发用于核酸的灵敏和快速多重传感。新添加的磁性区域在弱均匀磁场的存在下获得了偶极矩，允许颗粒沿着施加的磁场方向排列。新的磁性特性已经导致在生物测定期间条形码化微粒的有效取向和分离中的实际应用，而不破坏检测能力。
Magnetic polymer particles have been used in a wide variety of applications ranging from targeting and separation to diagnostics and imaging. Current synthesis methods have limited these particles to spherical or deformations of spherical morphologies. In this paper, we report the use of stop flow lithography to produce magnetic hydrogel microparticles with a graphical code region, a probe region, and a magnetic tail region. These anisotropic multifunctional magnetic polymer particles are an enhanced version of previously synthesized “barcoded” particles [ref. ] developed for the sensitive and rapid multiplexed sensing of nucleic acids. The newly added magnetic region has acquired dipole moments in the presence of weak homogeneous magnetic fields, allowing the particles to align along the applied field direction. The novel magnetic properties have led to practical applications in the efficient orientation and separation of the barcoded microparticles during biological assays without disrupting detection capabilities.
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