TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda.
TERT rs2736100 and TERC rs16847897 genotypes moderate the association between internalizing mental disorders and accelerated telomere length attrition among HIV+ children and adolescents in Uganda.
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DOI：
10.1186/s12920-020-00857-z
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发表时间：
2021-01-06
影响因子：
2.7
通讯作者：
Hemmings SMJ
中科院分区：
文献类型：
--
作者：
Kalungi A;Kinyanda E;Womersley JS;Joloba ML;Ssembajjwe W;Nsubuga RN;Kaleebu P;Levin J;Kidd M;Seedat S;Hemmings SMJ
内化精神障碍（IMDs）（抑郁、焦虑和创伤后应激障碍）与端粒长度（TL）加速损耗有关；然而，这种关联尚未在影响TL的遗传变异背景下进行研究。我们之前报道了乌干达艾滋病毒阳性儿童和青少年中imd与TL加速消耗之间的关联。本研究研究了端粒酶逆转录酶基因（TERT） （rs2736100、rs7726159、rs10069690和rs2853669）和端粒酶RNA成分基因（TERC） （rs12696304、rs16847897和rs10936599）中选择性单核苷酸多态性对乌干达HIV阳性儿童（5-11岁）和青少年（12-17岁）imd和TL相关性的调节作用。我们发现imd作为一个组与基线时TL上任何选定的snp之间没有显著的相互作用。我们观察到IMDs在12个月时分别与TERT rs2736100 （p = 0.007）和TERC rs16847897 （p = 0.012）有显著的相互作用。TERT rs2736100和TERC rs16847897调节乌干达HIV阳性儿童和青少年12个月时imd和TL之间的关联。了解这种关联的本质可能有助于揭示IMDs中细胞晚期衰老的病理生理机制。
Internalizing mental disorders (IMDs) (depression, anxiety and post-traumatic stress disorder) have been associated with accelerated telomere length (TL) attrition; however, this association has not been investigated in the context of genetic variation that has been found to influence TL. We have previously reported an association between IMDs and accelerated TL attrition among Ugandan HIV+ children and adolescents. This study investigated the moderating effects of selected single nucleotide polymorphisms in the telomerase reverse transcriptase gene (TERT) (rs2736100, rs7726159, rs10069690 and rs2853669) and the telomerase RNA component gene (TERC) (rs12696304, rs16847897 and rs10936599) on the association between IMDs and TL, among Ugandan HIV+ children (aged 5–11 years) and adolescents (aged 12–17 years). We found no significant interaction between IMDs as a group and any of the selected SNPs on TL at baseline. We observed significant interactions of IMDs with TERT rs2736100 (p = 0.007) and TERC rs16847897 (p = 0.012), respectively, on TL at 12 months. TERT rs2736100 and TERC rs16847897 moderate the association between IMDs and TL among Ugandan HIV+ children and adolescents at 12 months. Understanding the nature of this association may shed light on the pathophysiological mechanisms underlying advanced cellular aging in IMDs.
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影响因子：
4.4
作者：
Bhatia, Ramona;Hartman, Christine;Giordano, Thomas P.
通讯作者：
Giordano, Thomas P.
影响因子：
15.1
作者：
Garcia-Rizo, Clemente;Fernandez-Egea, Emilio;Kirkpatrick, Brian
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Kirkpatrick, Brian
DOI：
10.1073/pnas.1820838116
发表时间：
2020-09-22
影响因子：
11.1
作者：
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通讯作者：
O'Donnell, Kieran J.
影响因子：
3.7
作者：
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通讯作者：
Verhulst, Frank C.
影响因子：
56.9
作者：
Gabriel, SB;Schaffner, SF;Altshuler, D
通讯作者：
Altshuler, D