Outcomes for circulatory death and brainstem death pancreas transplantation with or without use of normothermic regional perfusion.

Outcomes for circulatory death and brainstem death pancreas transplantation with or without use of normothermic regional perfusion.
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DOI:
10.1093/bjs/znab212
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发表时间:
2021-12-01
期刊:
The British journal of surgery
影响因子:
--
通讯作者:
Pettigrew GJ
Pettigrew GJ
中科院分区:
其他
文献类型:
--
作者:
Richards JA;Roberts JL;Fedotovs A;Paul S;Cottee S;Defries G;Watson CJE;Pettigrew GJ

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胰腺和肾脏联合移植是1型糖尿病合并肾功能衰竭患者的最佳治疗方法,与单独进行已故供体肾移植相比,可提供生存益处。在这里,作者证明,利用循环死亡后的胰腺捐赠是一种安全的方法,可以扩大供体池,其结果与脑干死亡移植后的捐赠相同。他们还证明,在常温区域灌流后进行胰腺移植是可行的,但还需要进行前瞻性研究,以确保肝移植的好处不会以牺牲胰腺移植的结果为代价。
Simultaneous pancreas and kidney transplantation is the optimum treatment for patients with type 1 diabetes and renal failure, providing survival benefit over deceased donor kidney transplant alone. Here the authors demonstrate that utilization of donation after circulatory death pancreases is a safe approach to expanding the donor pool with equivalent results to donation after brainstem death transplantation. They also demonstrate that pancreas transplantation after normothermic regional perfusion is feasible, but it will require ongoing prospective study to ensure that the benefits seen for liver transplantation do not come at the expense of pancreas transplant outcomes.
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