Wireless-Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing.
Wireless-Powered Electrical Bandage Contact Lens for Facilitating Corneal Wound Healing.
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无线供电的电动绷带隐形眼镜，促进角膜伤口愈合。
DOI：
10.1002/advs.202202506
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发表时间：
2022-11
期刊：
影响因子：
15.1
通讯作者：
Chen, Weirong
中科院分区：
文献类型：
--
作者：
Wu, Qianni;Yang, Cheng;Chen, Wan;Chen, Kexin;Chen, Hui-jiuan;Liu, Fanmao;Liu, Dong;Lin, Haotian;Xie, Xi;Chen, Weirong
角膜损伤可导致严重的视力障碍甚至失明。尽管开发了许多方法来加速角膜伤口愈合，但其中大多数是被动治疗，很少参与控制内源性细胞行为或与不透明绷带不相容。在这项工作中，开发了一种无线供电的电动绷带接触透镜（EBCL），以产生局部外部电场，加速角膜伤口愈合和视力恢复。无线电刺激电路采用花形布局设计，可紧凑集成在绷带接触透镜上，不遮挡视线。体外实验观察了外加电场对角膜伤口愈合的促进作用，观察了角膜细胞对电场的定向迁移和排列反应。RNA测序（RNA-seq）分析表明，电刺激可以参与控制细胞分裂，增殖和迁移。此外，无线EBCL被证明可以加速电刺激兔眼角膜伤口的完全恢复，而对照组表现出延迟恢复和明显的角膜缺损。作为新一代智能设备，无线和患者友好的EBCL可以为眼部疾病提供有前途的治疗策略。此处讨论了无线供电的电动绷带接触透镜（EBCL）促进角膜伤口愈合的示意图。佩戴在患者眼上的无线EBCL产生的外电场能够调节角膜上皮细胞的行为，从而加速角膜伤口的修复和患者视力的恢复。
Corneal injury can lead to severe vision impairment or even blindness. Although numerous methods are developed to accelerate corneal wound healing, most of them are passive treatments that rarely participate in controlling endogenous cell behaviors or are incompatible with nontransparent bandage. In this work, a wireless‐powered electrical bandage contact lens (EBCL) is developed to generate a localized external electric field to accelerate corneal wound healing and vision recovery. The wireless electrical stimulation circuit employed a flower‐shaped layout design that can be compactly integrated on bandage contact lens without blocking the vision. The role of the external electric field in promoting corneal wound healing is examined in vitro, where the responses of directional migration and corneal cells alignment to the electric field are observed. The RNA sequencing (RNA‐seq) analysis indicates that the electrical stimulation can participate in controlling cell division, proliferation, and migration. Furthermore, the wireless EBCL is demonstrated to accelerate the completed recovery of corneal wounds on rabbits’ eyes by electrical stimulation, while the control group exhibits delayed recovery and obvious corneal defects. As a new generation of intelligent device, the wireless and patient‐friendly EBCL can provide a promising therapeutic strategy for ocular diseases. Schematic of the wireless‐powered electrical bandage contact lens (EBCL) promoting cornea wound healing is discussed here. External electric field produced by the wireless EBCL worn on patient’ eye is capable of regulating the behavior of corneal epithelial cells, thus accelerating corneal wound repair and the recovery of patient's vision.
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影响因子：
3.4
作者：
Cao, Lin;Zhang, Xiao-Dong;Liu, Xiaobo;Chen, Tsung-Yu;Zhao, Min
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影响因子：
17.8
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Rootman, D
影响因子：
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影响因子：
5.6
作者：
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通讯作者：
Collinson, J. Martin