Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects.
Weight Loss and Malnutrition in Patients with Parkinson's Disease: Current Knowledge and Future Prospects.
复制标题
帕金森病患者的体重减轻和营养不良：当前知识和未来前景
DOI：
10.3389/fnagi.2018.00001
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发表时间：
2018
影响因子：
4.8
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Ma K;Xiong N;Shen Y;Han C;Liu L;Zhang G;Wang L;Guo S;Guo X;Xia Y;Wan F;Huang J;Lin Z;Wang T
帕金森病（Parkinson's Disease，PD）是一种全身性神经退行性疾病，不仅表现为运动症状，还表现为非运动症状。特别是，体重减轻和营养不良，一组经常被忽视的非运动症状，确实与PD患者的生活质量呈负相关。此外，体重减轻和营养不良的共病可能影响疾病进展，引起运动障碍、认知能力下降和直立性低血压，甚至导致残疾和死亡。然而，PD患者体重减轻和营养不良的潜在机制仍不清楚，可能涉及众多的外源性或内源性因素。更重要的是，目前还没有任何减肥和营养不良的评价标准和管理策略。鉴于此，在本文中，我们阐述了PD的体重减轻和营养不良的研究现状，并总结了潜在的决定因素和机制。总之，我们目前的知识和未来的前景，减肥和营养不良的背景下，PD，旨在呼吁临床医生和研究人员更加密切地关注这一现象，使更好的管理和治疗策略，在未来的临床实践。
Parkinson's Disease (PD) is currently considered a systemic neurodegenerative disease manifested with not only motor but also non-motor symptoms. In particular, weight loss and malnutrition, a set of frequently neglected non-motor symptoms, are indeed negatively associated with the life quality of PD patients. Moreover, comorbidity of weight loss and malnutrition may impact disease progression, giving rise to dyskinesia, cognitive decline and orthostatic hypotension, and even resulting in disability and mortality. Nevertheless, the underlying mechanism of weight loss and malnutrition in PD remains obscure and possibly involving multitudinous, exogenous or endogenous, factors. What is more, there still does not exist any weight loss and malnutrition appraision standards and management strategies. Given this, here in this review, we elaborate the weight loss and malnutrition study status in PD and summarize potential determinants and mechanisms as well. In conclusion, we present current knowledge and future prospects of weight loss and malnutrition in the context of PD, aiming to appeal clinicians and researchers to pay a closer attention to this phenomena and enable better management and therapeutic strategies in future clinical practice.
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DOI：
10.1523/jneurosci.3890-09.2009
发表时间：
2009-11-11
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Andrews ZB;Erion D;Beiler R;Liu ZW;Abizaid A;Zigman J;Elsworth JD;Savitt JM;DiMarchi R;Tschoep M;Roth RH;Gao XB;Horvath TL
通讯作者：
Horvath TL
影响因子：
9.9
作者：
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通讯作者：
Alves, Guido
影响因子：
5.1
作者：
Bachmann, C. G.;Zapf, A.;Trenkwalder, C.
通讯作者：
Trenkwalder, C.
影响因子：
4.8
作者：
Aarsland, Dag;Beyer, Mona K.;Kurz, Martin W.
通讯作者：
Kurz, Martin W.
影响因子：
3.6
作者：
Barichella, Michela;Villa, Maria Chiara;Pezzoli, Gianni
通讯作者：
Pezzoli, Gianni