PathoPlant: a platform for microarray expression data to analyze co-regulated genes involved in plant defense responses.
PathoPlant: a platform for microarray expression data to analyze co-regulated genes involved in plant defense responses.
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DOI：
10.1093/nar/gkl835
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发表时间：
2007-01
影响因子：
14.9
通讯作者：
Hehl R
中科院分区：
文献类型：
--
作者：
Bülow L;Schindler M;Hehl R
植物通过表达针对感染病原体的特异性蛋白质来对病原体攻击作出反应。这涉及特定基因组的转录激活。PathoPlant®是一个关于植物-病原体相互作用和信号转导反应的数据库，现在已经得到了来自受到病原体感染和激发子处理的拟南芥的微阵列基因表达数据的补充。新的网络工具能够识别受特定刺激调控的植物基因。还可以显示由多种刺激共调节的基因组。创建了一个用户友好的网络界面，用于提交待分析的基因集。这将导致一个表格，列出了对相应基因起诱导或抑制作用的刺激。搜索可以限于某些诱导因子以鉴定例如强烈上调或下调的基因。最多可将三种刺激与诱导因子限制的选择相结合，以确定类似的调节基因。为了鉴定共调控基因中的共同顺式调控元件，可以将所得基因列表直接导出到AthaMap数据库进行分析。PathoPlant可免费访问。
Plants react to pathogen attack by expressing specific proteins directed toward the infecting pathogens. This involves the transcriptional activation of specific gene sets. PathoPlant®, a database on plant–pathogen interactions and signal transduction reactions, has now been complemented by microarray gene expression data from Arabidopsis thaliana subjected to pathogen infection and elicitor treatment. New web tools enable identification of plant genes regulated by specific stimuli. Sets of genes co-regulated by multiple stimuli can be displayed as well. A user-friendly web interface was created for the submission of gene sets to be analyzed. This results in a table, listing the stimuli that act either inducing or repressing on the respective genes. The search can be restricted to certain induction factors to identify, e.g. strongly up- or down-regulated genes. Up to three stimuli can be combined with the option of induction factor restriction to determine similarly regulated genes. To identify common cis-regulatory elements in co-regulated genes, a resulting gene list can directly be exported to the AthaMap database for analysis. PathoPlant is freely accessible at .
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