Stunting among children aged 24-59 months and associations with sanitation, enteric infections, and environmental enteric dysfunction in rural northwest Ethiopia.
Stunting among children aged 24-59 months and associations with sanitation, enteric infections, and environmental enteric dysfunction in rural northwest Ethiopia.
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DOI：
10.1038/s41598-022-23981-5
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发表时间：
2022-11-11
影响因子：
4.6
通讯作者：
中科院分区：
文献类型：
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作者：
发育迟缓是一个全球关注的公共卫生问题。尽管卫生条件差、腹泻、寄生虫感染和环境性肠功能障碍（EED）与发育迟缓有关，但人们对它们之间的联系知之甚少，也没有在埃塞俄比亚进行调查。本研究旨在评估埃塞俄比亚西北部农村地区24-59个月儿童发育迟缓与卫生条件、肠道感染和EED之间的关系。在东登比亚区农村地区随机选择224名24-59个月的儿童进行了一项以社区为基础的横断面研究。我们使用从食品和营养技术援助（FANTA）项目中采用的预测试问卷收集了有关家庭粮食不安全和饮食多样性的信息。我们使用身高与年龄比值（HAZ）来定义发育迟缓。我们还使用收集的数据来测量儿童对肠道寄生虫感染的环境暴露和EED的粪便生物标志物。采用多变量二元logistic回归模型评估发育迟缓与卫生条件、肠道感染和EED之间的关系。在224名儿童中，33% （95% CI 27,39%）发育不良。发育迟缓儿童明显与贫穷有关饮食摄入量(优势比3.0,95% CI 1.2, 7.3),排便实践(优势比3.0,95% CI 1.2, 7.9),动物排泄物的生活环境(优势比3.4,95% CI 1.2, 9.9),大肠杆菌污染的饮用水(优势比4.2,95% CI 1.1, 15.3),腹泻发病率(优势比3.4,95% CI 1.5, 7.7),儿童肠道寄生虫(优势比3.3,95% CI 1.3, 8.8),和更高的速度疾病活动分数(优势比2.9,95% CI 1.2, 6.7)。研究地区三分之一的儿童发育迟缓，而发育迟缓的高发率与不良的饮食摄入、不良的卫生和环境卫生条件、肠道感染和EED有关。因此，通过改善环境卫生和个人卫生条件以防止儿童反复肠道感染和促进儿童饮食多样性，可以预防发育迟缓。
Stunting is a public health issue of global concern. Despite, poor sanitation, diarrhea, parasitic infections, and environmental enteric dysfunction (EED) are associated with stunting, their link is poorly understood and has not been investigated in Ethiopia. This study was conducted to assess the associations of stunting with sanitation, enteric infections, and EED among children aged 24–59 months in rural northwest Ethiopia. A community-based cross-sectional study was conducted among 224 randomly selected children aged 24–59 months in rural areas of the east Dembiya district. We collected information on household food insecurity and dietary diversity using pre-tested questionnaires adopted from the food and nutrition technical assistance (FANTA) project. We used height-for-age-z score (HAZ) to define stunting. We also used the data collected to measure the environmental exposures of children to intestinal parasitic infections and fecal biomarkers of EED. A multivariable binary logistic regression model was used to assess the association of stunting with sanitation, enteric infections, and EED. Of the 224 children, 33% (95% CI 27, 39%) were stunted. Stunting in children was significantly associated with poor dietary intake (AOR 3.0, 95% CI 1.2, 7.3), open defecation practice (AOR 3.0, 95% CI 1.2, 7.9), presence of animal excreta in the living environment (AOR 3.4, 95% CI 1.2, 9.9), E. coli contamination of drinking water (AOR 4.2, 95% CI 1.1, 15.3), diarrheal disease incidence (AOR 3.4, 95% CI 1.5, 7.7), intestinal parasites in children (AOR 3.3, 95% CI 1.3, 8.8), and higher EED disease activity scores (AOR 2.9, 95% CI 1.2, 6.7). One-third of the children in the study area were stunted and this high prevalence of stunting was associated with poor dietary intake, poor hygiene and sanitation conditions, enteric infections, and EED. Thus, stunting can be prevented by improving sanitation and hygienic conditions to prevent repeated enteric infections in children and by promoting dietary diversity of children.
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与无障碍儿童相比，有改善卫生但没有改善水的儿童患有阻碍：在埃塞俄比亚，印度，秘鲁和越南进行的同类研究。
影响因子：
4.5
作者：
Dearden KA;Schott W;Crookston BT;Humphries DL;Penny ME;Behrman JR;Young Lives Determinants and Consequences of Child Growth Project Team
通讯作者：
Young Lives Determinants and Consequences of Child Growth Project Team
影响因子：
1.2
作者：
Eshete, Hiwot;Abebe, Yewelsew;Tesheme, Tesfalem
通讯作者：
Tesheme, Tesfalem
影响因子：
168.9
作者：
Black, Robert E.;Victora, Cesar G.;Uauy, Ricardo
通讯作者：
Uauy, Ricardo
影响因子：
--
作者：
Dodos, J.;Mattern, B.;Aissa, M. A.
通讯作者：
Aissa, M. A.
影响因子：
2.2
作者：
Afework E;Mengesha S;Wachamo D
通讯作者：
Wachamo D