Strengthening relationships: amyloids create adhesion nanodomains in yeasts.
Strengthening relationships: amyloids create adhesion nanodomains in yeasts.
复制标题
DOI：
10.1016/j.tim.2011.10.002
复制
发表时间：
2012-02
影响因子：
15.9
通讯作者：
Dufrene, Yves F.
中科院分区：
文献类型：
--
作者：
Lipke, Peter N.;Garcia, Melissa C.;Alsteens, David;Ramsook, Caleen B.;Klotz, Stephen A.;Dufrene, Yves F.
Budding yeasts adhere to biotic or abiotic surfaces and aggregate to form biofilms, using wall-anchored glycoprotein adhesins. The process is paradoxical: adhesins often show weak binding to specific ligands, yet mediate remarkably strong adherence. Single-molecule atomic force microscopy, genomics, biochemistry, and cell biology have recently explained the puzzle, with Candida albicans Als adhesins as the paradigm. The strength of adhesion results partly from force-activated amyloid-like clustering of hundreds of adhesin molecules to form arrays of ordered multimeric binding sites. The various protein domains of eukaryotic adhesins cooperate to facilitate this fascinating new mechanism of activation.
登录
查看更多内容
影响因子：
--
作者：
Gaur, NK;Smith, RL;Klotz, SA
通讯作者：
Klotz, SA
影响因子：
17.1
作者：
Alsteens, David;Dupres, Vincent;Klotz, Stephen A.;Gaur, Nand K.;Lipke, Peter N.;Dufrene, Yves F.
通讯作者：
Dufrene, Yves F.
白色念珠菌URE2P Prion结构域的淀粉样蛋白具有感染性，并具有并行的平行β-折叠结构。
影响因子：
2.9
作者：
Engel A;Shewmaker F;Edskes HK;Dyda F;Wickner RB
通讯作者：
Wickner RB
影响因子：
--
作者：
Frank, Aaron T.;Ramsook, Caleen B.;Lipke, Peter N.
通讯作者：
Lipke, Peter N.
影响因子：
2.8
作者：
Gaur, NK;Klotz, SA
通讯作者：
Klotz, SA