Conventional MRI-based subchondral trabecular biomarkers as predictors of knee osteoarthritis progression: data from the Osteoarthritis Initiative.
Conventional MRI-based subchondral trabecular biomarkers as predictors of knee osteoarthritis progression: data from the Osteoarthritis Initiative.
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传统的基于MRI的软骨下骨小梁生物标记物作为膝关节骨关节炎进展的预测因子：来自骨关节炎倡议的数据。
DOI：
10.1007/s00330-020-07512-2
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发表时间：
2021-06
影响因子：
5.9
通讯作者：
中科院分区：
文献类型：
--
作者：
评价在“常规”中等加权（IW）MRI序列中测量软骨下骨小梁生物标志物的可靠性和有效性，并评估生物标志物变化对预测膝骨关节炎（OA）近期症状和结构进展的预测价值。对于这项研究，开发了一个框架，用于测量“传统”IW MRI序列中胫骨近端内侧的骨小梁生物标志物。在骨辅助研究（骨关节炎倡议[OAI]内）中评价了测量这些生物标志物（骨小梁厚度[cTbTh]、间距[cTbSp]、连接密度[cConnD]和骨与总体积比[cBV/TV]）的可靠性。通过比较“表观”生物标志物（来自高分辨率稳态MRI序列）和关节周围骨髓密度（BMD，来自双能X线吸收测定法）来评估这些测量的有效性。FNIH OA生物标志物联盟（OAI内）研究了这些生物标志物从基线至24个月的变化（使用可靠变化指数）与膝关节OA进展的相关性。通过比较基线WOMAC疼痛评分和影像学关节间隙宽度与24-48个月评分/测量值，评价疼痛和影像学进展。使用针对相关协变量调整的逻辑回归研究生物标志物变化与这些结果之间的关联。在可接受的可靠性下，cTbTh和cBV/TV（而不是cTbSp或cConnD）与“表观”生物标志物和关节周围BMD适度相关（分别为β：1.10 [95% CI：0.45-1.75]，p值：0.001和β：3.69 [95% CI：2.56-4.83]，p值：< 0.001）。cTbTh升高的膝关节（OR：1.44 [95% CI：1.03-2.02]，p值：0.035）和cTbTh降低的膝关节（OR：0.69 [95% CI：0.49-0.95]，p值：0.026）或cBV/TV降低（OR：0.67 [95% CI：0.48-0.93]，p值：0.018）在随访期间发生OA疼痛进展的几率较低。某些“传统的”基于MRI的软骨下骨小梁生物标志物的测量具有较高的可靠性和适度的有效性。尽管这些生物标志物的变化不大，但在48个月的随访中，这些生物标志物的变化与膝关节OA疼痛进展之间存在显著相关性。
To evaluate the reliability and validity of measuring subchondral trabecular biomarkers in “conventional” intermediate-weighted (IW) MRI sequences and to assess the predictive value of biomarker changes for predicting near-term symptomatic and structural progressions in knee osteoarthritis (OA). For this study, a framework for measuring trabecular biomarkers in the proximal medial tibia in the “conventional” IW MRI sequence was developed. The reliability of measuring these biomarkers (trabecular thickness [cTbTh], spacing [cTbSp], connectivity density [cConnD], and bone-to-total volume ratio [cBV/TV]) was evaluated in the Bone Ancillary Study (within die Osteoarthritis Initiative [OAI]). The validity of these measurements was assessed by comparing to “apparent” biomarkers (from high-resolution steady-state MRI sequence) and peri-articular bone marrow density (BMD, from dual-energy X-ray absorptiometry). The association of these biomarker changes from baseline to 24 months (using the Reliable Change Index) with knee OA progression was studied in the FNIH OA Biomarkers Consortium (within the OAI). Pain and radiographic progression were evaluated by comparing baseline WOMAC pain score and radiographic joint space width with the 24-to-48-month scores/measurements. Associations between biomarker changes and these outcomes were studied using logistic regression adjusted for the relevant covariates. With acceptable reliability, the cTbTh and cBV/TV, but not cTbSp or cConnD, were modestly associated with the “apparent” biomarkers and peri-articular BMD (β: 1.10 [95% CI: 0.45–1.75], p value: 0.001 and β: 3.69 [95% CI: 2.56–4.83], p value: < 0.001, respectively). Knees with increased cTbTh had higher (OR: 1.44 [95% CI: 1.03–2.02], p value: 0.035) and knees with decreased cTbTh (OR: 0.69 [95% CI: 0.49–0.95], p value: 0.026) or decreased cBV/TV (OR: 0.67 [95% CI: 0.48–0.93], p value: 0.018) had lower odds of experiencing OA pain progression over the follow-ups. Measurement of certain “conventional” MRI-based subchondral trabecular biomarkers has high reliability and modest validity. Though modest, there are significant associations between these biomarker changes and knee OA pain progression up to 48-month follow-up.
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DOI：
10.1016/s0140-6736(18)32203-7
发表时间：
2018-11-10
期刊：
Lancet (London, England)
影响因子：
--
作者：
GBD 2017 Causes of Death Collaborators
通讯作者：
GBD 2017 Causes of Death Collaborators
影响因子：
7
作者：
Birch CE;Mensch KS;Desarno MJ;Beynnon BD;Tourville TW
通讯作者：
Tourville TW
影响因子：
2.3
作者：
Bedson, John;Croft, Peter R.
通讯作者：
Croft, Peter R.
影响因子：
5.6
作者：
Sharma AR;Jagga S;Lee SS;Nam JS
通讯作者：
Nam JS
影响因子：
4.9
作者：
Lowitz, Torsten;Museyko, Oleg;Engelke, Klaus
通讯作者：
Engelke, Klaus