modMine: flexible access to modENCODE data.

modMine: flexible access to modENCODE data.
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DOI:
10.1093/nar/gkr921
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发表时间:
2012-01
影响因子:
14.9
通讯作者:
Micklem G
Micklem G
中科院分区:
生物学2区
文献类型:
--
作者:
Contrino S;Smith RN;Butano D;Carr A;Hu F;Lyne R;Rutherford K;Kalderimis A;Sullivan J;Carbon S;Kephart ET;Lloyd P;Stinson EO;Washington NL;Perry MD;Ruzanov P;Zha Z;Lewis SE;Stein LD;Micklem G

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为了全面表征重要模式生物黑果蝇和秀丽隐杆线虫基因组中的功能元件,NHGRI模式生物DNA元件百科全书(modENCODE)联盟已经生成了一个庞大的基因组数据库,以及关于实验各个方面的详细结构化信息。这里描述的modMine数据库(http://intermine.modencode.org)是由modENCODE数据协调中心建立的,允许更广泛的研究社区(i)搜索和下载由modENCODE生成的数千个感兴趣的数据集;(ii)与非modencode数据集一起以综合形式访问数据;(iii)便于对上述数据进行细粒度分析。复杂的搜索功能之所以成为可能,是因为该联盟收集了大量的实验元数据。提供接口,允许生物学家和生物信息学家利用这些丰富的modcode数据集,现在可以通过modMine获得。
In an effort to comprehensively characterize the functional elements within the genomes of the important model organisms Drosophila melanogaster and Caenorhabditis elegans, the NHGRI model organism Encyclopaedia of DNA Elements (modENCODE) consortium has generated an enormous library of genomic data along with detailed, structured information on all aspects of the experiments. The modMine database (http://intermine.modencode.org) described here has been built by the modENCODE Data Coordination Center to allow the broader research community to (i) search for and download data sets of interest among the thousands generated by modENCODE; (ii) access the data in an integrated form together with non-modENCODE data sets; and (iii) facilitate fine-grained analysis of the above data. The sophisticated search features are possible because of the collection of extensive experimental metadata by the consortium. Interfaces are provided to allow both biologists and bioinformaticians to exploit these rich modENCODE data sets now available via modMine.
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发表时间: 2011-01
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