Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions.
Epithelial integrity, junctional complexes, and biomarkers associated with intestinal functions.
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DOI：
10.1080/21688370.2021.1996830
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发表时间：
2022-07-03
期刊：
影响因子：
3.1
通讯作者：
Braber, Saskia
中科院分区：
文献类型：
--
作者：
Alizadeh, Arash;Akbari, Peyman;Garssen, Johan;Fink-Gremmels, Johanna;Braber, Saskia
关键词：
完整的肠屏障对于免疫稳态至关重要，其损伤激活免疫系统并可能导致慢性炎症。肠屏障的上皮细胞通过紧密连接连接，紧密连接形成封闭相邻上皮细胞的封闭网络。紧密连接由跨膜和细胞质支架蛋白组成。细胞顶侧膜上的跨膜紧密连接蛋白包括闭合蛋白、紧密连接蛋白、连接粘附分子和三纤维素。细胞质支架蛋白，包括闭锁小带、扣带蛋白和afadin，提供跨膜紧密连接蛋白和细胞内细胞骨架之间的直接联系。紧密连接网络的每个单独的组分彼此紧密相互作用以形成有效的肠屏障。本文综述了肠上皮细胞紧密连接蛋白的分子结构及其相互作用。此外，临床上重要的生物标志物与胃肠道完整性的损害进行了讨论。
An intact intestinal barrier is crucial for immune homeostasis and its impairment activates the immune system and may result in chronic inflammation. The epithelial cells of the intestinal barrier are connected by tight junctions, which form an anastomosing network sealing adjacent epithelial cells. Tight junctions are composed of transmembrane and cytoplasmic scaffolding proteins. Transmembrane tight junction proteins at the apical-lateral membrane of the cell consist of occludin, claudins, junctional adhesion molecules, and tricellulin. Cytoplasmic scaffolding proteins, including zonula occludens, cingulin and afadin, provide a direct link between transmembrane tight junction proteins and the intracellular cytoskeleton. Each individual component of the tight junction network closely interacts with each other to form an efficient intestinal barrier. This review aims to describe the molecular structure of intestinal epithelial tight junction proteins and to characterize their organization and interaction. Moreover, clinically important biomarkers associated with impairment of gastrointestinal integrity are discussed.
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影响因子：
2.4
作者：
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通讯作者：
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作者：
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影响因子：
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通讯作者：
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