Prenatal lead exposure and elevated blood pressure in children.
Prenatal lead exposure and elevated blood pressure in children.
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DOI：
10.1016/j.envint.2018.10.049
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发表时间：
2018-12
影响因子：
11.8
通讯作者：
Karagas MR
中科院分区：
文献类型：
--
作者：
Farzan SF;Howe CG;Chen Y;Gilbert-Diamond D;Cottingham KL;Jackson BP;Weinstein AR;Karagas MR
越来越多的证据表明，环境暴露会影响一生中的血压。暴露于有毒金属，如铅（Pb）和砷（As），与成人血压升高有关，但很少有研究探讨宫内和生命早期接触有毒金属对儿童血压的影响。由于亚临床血管变化被认为在生命早期开始，因此子宫内有毒金属暴露可能在血压稳态中发挥作用。在正在进行的新罕布什尔州出生队列研究中，我们调查了323名幼儿（平均年龄5.5岁，SD 0.4）子宫内铅和砷暴露是否与血压测量相关。在妊娠28周（n= 257）和/或产后6周（n = 285）采集的母亲趾甲样本中测量了Pb和As，这代表了采集前6至12个月的暴露，因此分别反映了早期产前和晚期产前暴露。使用标准化技术对每个儿童的五次收缩压（SBP）和舒张压（DBP）测量值进行平均。在线性回归分析中，对log 2转换的产前趾甲Pb和As进行联合建模，并根据儿童年龄、性别、身高、体重和母亲怀孕期间吸烟进行调整，我们观察到母亲产前趾甲Pb加倍与儿童SBP统计学显著增加相关（β：0.58 mmHg，95% CI：0.05，1.11）。我们没有观察到产前或产后As或产后Pb与SBP或DBP的任何关联。探索性性别分层分析表明，产前铅与血压的关联可能在男孩中更强（SBP β：0.72 mmHg：95% CI：−0.01，1.44; DBP β：0.37; 95% CI：−0.09，0.84），与女孩相比（SBP β：0.48 mmHg：95% CI：−0.31，1.26; DBP β：−0.05; 95% CI：−0.52，0.41），但相互作用检验未达到统计学显著性（p-相互作用SBP = 0.059; DBP = 0.057）。我们的初步结果表明，在子宫内接触有毒金属可能与儿童早期血压升高有关，这可能对长期健康产生影响。
Growing evidence suggests that environmental exposures can influence blood pressure over the course of a lifetime. Exposure to toxic metals, such as lead (Pb) and arsenic (As), has been associated with increased blood pressure in adults, but few studies have examined the impacts of in utero and early life toxic metals exposure on blood pressure in childhood. As subclinical vascular changes are thought to begin early in life, it is possible that in utero toxic metals exposure may play a role in blood pressure homeostasis. In the ongoing New Hampshire Birth Cohort Study, we investigated whether in utero exposure to Pb and As was associated with measures of blood pressure in a total of 323 young children (mean age 5.5 years, SD 0.4). Pb and As were measured in maternal toenail samples collected at ~28 weeks gestation (n= 257) and/or 6 weeks postpartum (n = 285), which represent exposures ~6 to 12 months prior to collection and therefore reflect the early prenatal and late prenatal exposures, respectively. Five measurements of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were averaged for each child using a standardized technique. In linear regression analyses, where log2-transformed prenatal toenail Pb and As were modeled jointly and adjusted for child age, sex, height, weight and maternal smoking during pregnancy, we observed that a doubling of maternal prenatal toenail Pb was associated with statistically significant increases in child SBP (β: 0.58 mmHg, 95% CI: 0.05, 1.11). We did not observe any association of prenatal or postpartum As, or postpartum Pb, with SBP or DBP. Exploratory sex-stratified analyses suggest that associations of prenatal Pb with BP may be stronger among boys (SBP β: 0.72 mmHg: 95% CI: −0.01, 1.44; DBP β: 0.37; 95% CI: −0.09, 0.84), compared to girls (SBP β: 0.48 mmHg: 95% CI: −0.31, 1.26; DBP β: −0.05; 95% CI: −0.52, 0.41), though tests for interaction did not reach statistical significance (p-interaction SBP = 0.059; DBP = 0.057). Our preliminary results suggest that in utero toxic metals exposures may be associated with early life increases in blood pressure in children, which could have consequences for long-term health.
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影响因子：
24
作者：
Hartiala, Olli;Magnussen, Costan G.;Raitakari, Olli T.
通讯作者：
Raitakari, Olli T.
影响因子：
10.4
作者：
Barbosa F Jr;Tanus-Santos JE;Gerlach RF;Parsons PJ
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Parsons PJ
影响因子：
37.8
作者：
Davis, PH;Dawson, JD;Lauer, RM
通讯作者：
Lauer, RM
影响因子：
19.6
作者：
AVIV, A;JOHN, E;SPITZER, A
通讯作者：
SPITZER, A
影响因子：
2
作者：
Grashow R;Zhang J;Fang SC;Weisskopf MG;Christiani DC;Cavallari JM
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Cavallari JM