Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
Kif1b is essential for mRNA localization in oligodendrocytes and development of myelinated axons.
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DOI：
10.1038/ng.376
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发表时间：
2009-07
期刊：
影响因子：
30.8
通讯作者：
Talbot, William S.
中科院分区：
文献类型：
--
作者：
Lyons, David A.;Naylor, Stephen G.;Scholze, Anja;Talbot, William S.
The kinesin motor protein Kif1b has previously been implicated in the axonal transport of mitochondria and synaptic vesicles. More recently kif1b has been linked with susceptibility to Multiple Sclerosis (MS). Here we show that Kif1b is required for the localization of myelin basic protein mRNA to processes of myelinating oligodendrocytes in zebrafish. We observe the ectopic appearance of myelin-like membrane in kif1b mutants, coincident with the ectopic localization of myelin proteins in kif1b mutant oligodendrocyte cell bodies. These observations suggest the hypothesis that oligodendrocytes localize certain mRNA molecules, namely those encoding small basic proteins such as mbp, to prevent aberrant effects of these proteins elsewhere in the cell. We also find that Kif1b is required for outgrowth of some of the longest axons in the peripheral and central nervous systems. Our data demonstrate new functions of kif1b in vivo and provide insights into its possible roles in Multiple Sclerosis.
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影响因子：
10.5
作者：
Schlisio, Susanne;Kenchappa, Rajappa S.;Kaelin, William G., Jr.
通讯作者：
Kaelin, William G., Jr.
影响因子：
1.5
作者：
Sato, T;Takahoko, M;Okamoto, H
通讯作者：
Okamoto, H
影响因子：
6.2
作者：
Brösamle, C;Halpern, ME
通讯作者：
Halpern, ME
影响因子：
64.5
作者：
NANGAKU, M;SATOYOSHITAKE, R;HIROKAWA, N
通讯作者：
HIROKAWA, N
DOI：
10.1083/jcb.123.2.431
发表时间：
1993-10
期刊：
The Journal of cell biology
影响因子：
--
作者：
Ainger K;Avossa D;Morgan F;Hill SJ;Barry C;Barbarese E;Carson JH
通讯作者：
Carson JH