Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy.
Technological advances in the use of viral and non-viral vectors for delivering genetic and non-genetic cargos for cancer therapy.
复制标题
DOI：
10.1007/s13346-023-01362-3
复制
发表时间：
2023-11
影响因子：
5.4
通讯作者：
Barth, Stefan
中科院分区：
文献类型：
--
作者：
Dogbey, Dennis Makafui;Torres, Valeria Esperanza Sandoval;Fajemisin, Emmanuel;Mpondo, Liyabona;Ngwenya, Takunda;Akinrinmade, Olusiji Alex;Perriman, Adam W.;Barth, Stefan
全球癌症负担正在增加。其主流治疗方法面临的几个挑战已经形成了靶向递送系统发展的基础，以携带和分配抗癌有效载荷到其确定的目标。这种药物分子和基因有效载荷的位点特异性递送，选择性地靶向可药物生物标志物，旨在诱导细胞死亡，同时保留正常细胞，是癌症治疗的主要目标。病毒或非病毒传递载体的一个重要优势是，它具有穿透实体肿瘤随机排列和免疫抑制肿瘤微环境的累积能力，并且能够抵抗抗体介导的免疫反应。目前迫切需要结合合理蛋白质工程的生物技术方法来开发靶向递送系统，这些系统可以作为抗癌药物包装和分发的载体，以选择性地靶向和杀死癌细胞。多年来，这些化学和基因修饰的给药系统旨在药物分子在受体位点的分布和选择性积累，从而持续维持药物的高生物利用度，从而有效地抗肿瘤活性。在这篇综述中，我们重点介绍了最新的病毒和非病毒药物和基因传递系统以及正在开发的癌症治疗技术。
The burden of cancer is increasing globally. Several challenges facing its mainstream treatment approaches have formed the basis for the development of targeted delivery systems to carry and distribute anti-cancer payloads to their defined targets. This site-specific delivery of drug molecules and gene payloads to selectively target druggable biomarkers aimed at inducing cell death while sparing normal cells is the principal goal for cancer therapy. An important advantage of a delivery vector either viral or non-viral is the cumulative ability to penetrate the haphazardly arranged and immunosuppressive tumour microenvironment of solid tumours and or withstand antibody-mediated immune response. Biotechnological approaches incorporating rational protein engineering for the development of targeted delivery systems which may serve as vehicles for packaging and distribution of anti-cancer agents to selectively target and kill cancer cells are highly desired. Over the years, these chemically and genetically modified delivery systems have aimed at distribution and selective accumulation of drug molecules at receptor sites resulting in constant maintenance of high drug bioavailability for effective anti-tumour activity. In this review, we highlighted the state-of-the art viral and non-viral drug and gene delivery systems and those under developments focusing on cancer therapy.
登录
查看更多内容
影响因子：
3.7
作者：
Bayin, N. Sumru;Modrek, Aram S.;Placantonakis, Dimitris G.
通讯作者：
Placantonakis, Dimitris G.
影响因子：
8
作者：
Bozzuto G;Molinari A
通讯作者：
Molinari A
影响因子：
--
作者：
Akbarzadeh A;Rezaei-Sadabady R;Davaran S;Joo SW;Zarghami N;Hanifehpour Y;Samiei M;Kouhi M;Nejati-Koshki K
通讯作者：
Nejati-Koshki K
PAMAM树状聚合物作为癌症治疗的有效药物和基因递送纳米系统。
影响因子：
8.3
作者：
Abedi-Gaballu F;Dehghan G;Ghaffari M;Yekta R;Abbaspour-Ravasjani S;Baradaran B;Dolatabadi JEN;Hamblin MR
通讯作者：
Hamblin MR
将 FLAG 标记的重组腺相关病毒 2 固定到组织工程支架上，以改善细胞移植中的转基因递送
影响因子：
3.7
作者：
Li H;Zhang FL;Shi WJ;Bai XJ;Jia SQ;Zhang CG;Ding W
通讯作者：
Ding W