Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder.
Atypical pupillary light reflex and heart rate variability in children with autism spectrum disorder.
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DOI：
10.1007/s10803-012-1741-3
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发表时间：
2013-08
影响因子：
3.9
通讯作者：
Yao G
中科院分区：
文献类型：
--
作者：
Daluwatte C;Miles JH;Christ SE;Beversdorf DQ;Takahashi TN;Yao G
对152例ASD儿童、116例典型发育期(TD)儿童和36例非ASD神经发育障碍(NDDS)儿童的瞳孔光反射(PLR)进行了研究。同时测量心率变异性(HRV)以研究与ASD相关的自主神经系统(ANS)的潜在损害。结果表明，ASD组较TD组PLR潜伏期延长，相对收缩幅度降低，收缩/收缩时间缩短。NDD组也观察到类似的非典型PLR参数。在TD组中，年龄对9岁以下儿童的PLR潜伏期有显著影响，而在ASD和NDD组中，年龄对PLR潜伏期没有显著影响。ASD组和NDD组观察到非典型的HRV参数。ASD儿童PLR收缩幅度与平均心率呈显著负相关，而发育正常儿童PLR收缩幅度与平均心率无显著相关性。
We investigated pupillary light reflex (PLR) in 152 children with ASD, 116 typically developing (TD) children, and 36 children with non-ASD neurodevelopmental disorders (NDDs). Heart rate variability (HRV) was measured simultaneously to study potential impairments in the autonomic nervous system (ANS) associated with ASD. The results showed that the ASD group had significantly longer PLR latency, reduced relative constriction amplitude, and shorter constriction/redilation time than those of the TD group. Similar atypical PLR parameters were observed in the NDD group. A significant age effect on PLR latency was observed in children younger than 9 years in the TD group, but not in the ASD and NDD groups. Atypical HRV parameters were observed in the ASD and NDD groups. A significant negative correlation existed between the PLR constriction amplitude and average heart rate in children with an ASD, but not in children with typical development.
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影响因子：
1.3
作者：
Goodie, JL;Larkin, KT;Schauss, S
通讯作者：
Schauss, S
影响因子：
5.8
作者：
Bremner, Fion
通讯作者：
Bremner, Fion
DOI：
10.1097/00004583-198102000-00002
发表时间：
1981-01-01
影响因子：
13.3
作者：
KOOTZ, JP;COHEN, DJ
通讯作者：
COHEN, DJ
影响因子：
3.3
作者：
Bonnet, MH;Arand, DL
通讯作者：
Arand, DL
影响因子：
3.2
作者：
Daluwatte C;Miles JH;Yao G
通讯作者：
Yao G