Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study.
Adherence to the Mediterranean diet assessed by a novel dietary biomarker score and mortality in older adults: the InCHIANTI cohort study.
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DOI：
10.1186/s12916-021-02154-7
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发表时间：
2021-11-24
期刊：
影响因子：
9.3
通讯作者：
Cherubini A
中科院分区：
文献类型：
--
作者：
Hidalgo-Liberona N;Meroño T;Zamora-Ros R;Rabassa M;Semba R;Tanaka T;Bandinelli S;Ferrucci L;Andres-Lacueva C;Cherubini A
膳食生物标志物可以补充膳食调查问卷所做的膳食摄入量评估。我们基于地中海饮食食物组开发了一种后验饮食生物标志物评分，并评估了其与死亡率的关系。在InCHIANTI队列研究（意大利托斯卡纳）中，642名参与者（56%为女性），年龄≥65岁，具有完整的饮食生物标志物数据，随访20年。主要结果为全因死亡率、心血管死亡率和癌症死亡率。饮食生物标志物是从文献中选择的，并从研究中地中海饮食食物组的饮食摄入量的相关性分析中选择的。选择以下饮食生物标志物的基线水平：尿总多酚和白藜芦醇代谢物，血浆类胡萝卜素，硒，维生素B12，亚麻酸，二十碳五烯酸和二十二碳六烯酸，以及单不饱和/饱和脂肪酸比例。采用饮食生物标志物和经过验证的食物频率问卷（FFQ）评分（作为样本）的地中海饮食评分与死亡率的关系通过Cox回归进行评估。在20年的随访期间[中位数（Q1-Q3）， 14（8-18）年]，435人死亡（139人死于心血管疾病，89人死于癌症相关原因）。在完全调整的模型中，饮食生物标志物-地中海饮食评分与全因（HRT3vs）呈负相关。T1 0.72;95%CI 0.56-0.91)和心血管(HRT3vs。T1 0.60;95%CI 0.38-0.93)，但与癌症死亡率无关。ffq -地中海饮食评分与死亡率之间的关联无统计学意义。在20年的随访中，通过饮食生物标志物评分评估的地中海饮食在基线时的更大依从性与老年人较低的死亡风险相关。饮食生物标志物的测量可能有助于指导老年人的个性化饮食咨询。NCT01331512在线版本包含补充材料，可在10.1186/s12916-021-02154-7获得。
Dietary biomarkers may complement dietary intake assessment made by dietary questionnaires. We developed an a-posteriori dietary biomarkers score based on Mediterranean diet food groups and evaluated its association with mortality. 642 participants (56% female), aged ≥65 years, with complete data on dietary biomarkers were followed during 20 years in the InCHIANTI cohort study (Tuscany, Italy). The main outcomes were all-cause, cardiovascular, and cancer mortality. Dietary biomarkers were selected from literature and from correlation analyses with dietary intakes of Mediterranean diet food groups in the study. The baseline levels of the following dietary biomarkers were chosen: urinary total polyphenols and resveratrol metabolites, and plasma carotenoids, selenium, vitamin B12, linolenic, eicosapentaenoic and docosahexaenoic acids, and the mono-unsaturated/saturated fatty acid ratio. Associations of the Mediterranean diet score using dietary biomarkers and a validated food frequency questionnaire (FFQ) (as tertiles) with mortality were assessed through Cox regression. During the 20-year follow-up [median (Q1–Q3), 14 (8–18) years], and 435 deaths occurred (139 from cardiovascular diseases and 89 from cancer-related causes). In the fully adjusted models, the dietary biomarker-Mediterranean diet score was inversely associated with all-cause (HRT3vs.T1 0.72; 95%CI 0.56–0.91) and cardiovascular (HRT3vs.T1 0.60; 95%CI 0.38–0.93), but not with cancer mortality. Associations between the FFQ-Mediterranean diet score and mortality were not statistically significant. A greater adherence at baseline to a Mediterranean diet assessed by a dietary biomarker score was associated with a lower risk of mortality in older adults during a 20-year follow-up. The measurement of dietary biomarkers may contribute to guide individualized dietary counseling to older people. NCT01331512 The online version contains supplementary material available at 10.1186/s12916-021-02154-7.
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影响因子：
4.7
作者：
Al-Delaimy, WK;Ferrari, P;Riboli, E
通讯作者：
Riboli, E
DOI：
10.1111/j.1532-5415.2000.tb03873.x
发表时间：
2000-12-01
影响因子：
6.3
作者：
Ferrucci, L;Bandinelli, S;Guralnik, JM
通讯作者：
Guralnik, JM
DOI：
10.1093/gerona/61.6.589
发表时间：
2006-06-01
影响因子：
5.1
作者：
Bartali, Benedetta;Frongillo, Edward A.;Ferrucci, Luigi
通讯作者：
Ferrucci, Luigi
影响因子：
6.4
作者：
Buckland, G.;Travier, N.;Riboli, E.
通讯作者：
Riboli, E.
影响因子：
5.8
作者：
Ferrucci, L;Cherubini, A;Guralnik, JM
通讯作者：
Guralnik, JM