Case Report: Chronic Adaptive Deep Brain Stimulation Personalizing Therapy Based on Parkinsonian State.

Case Report: Chronic Adaptive Deep Brain Stimulation Personalizing Therapy Based on Parkinsonian State.
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病例报告:基于帕金森氏症的慢性自适应深度脑刺激个性化疗法。

DOI:
10.3389/fnhum.2021.702961
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发表时间:
2021
影响因子:
2.9
通讯作者:
Hattori N
Hattori N
中科院分区:
医学3区
文献类型:
--
作者:
Nakajima A;Shimo Y;Fuse A;Tokugawa J;Hishii M;Iwamuro H;Umemura A;Hattori N

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我们描述了一例51岁帕金森氏病(PD)患者,表现为运动波动,他接受了双侧丘脑深部刺激(DBS),使用自适应DBS设备,Percept™PC(美敦力公司,明尼阿波利斯,明尼苏达州)。这种装置可以根据靶结构上局部场势(LFP)的神经振荡的涨落来提供电刺激。我们观察到,医院内的LFP波动没有室外明显,而刺激成功地适应了aDBS阶段的β振荡波动,没有任何刺激诱导的副作用。因此,这种新的装置有助于条件依赖性刺激;这种新的刺激方法是可行的,并为帕金森病的病理生理机制提供了新的见解。
We describe the case of a 51-year-old man with Parkinson's disease (PD) presenting with motor fluctuations, who received bilateral subthalamic deep brain stimulation (DBS) with an adaptive DBS (aDBS) device, Percept™ PC (Medtronic, Inc. , Minneapolis, MN). This device can deliver electrical stimulations based on fluctuations of neural oscillations of the local field potential (LFP) at the target structure. We observed that the LFP fluctuations were less evident inside the hospital than outside, while the stimulation successfully adapted to beta oscillation fluctuations during the aDBS phase without any stimulation-induced side effects. Thus, this new device facilitates condition-dependent stimulation; this new stimulation method is feasible and provides new insights into the pathophysiological mechanisms of PD.
晚期帕金森病的自适应深脑刺激。
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