Case Report: Chronic Adaptive Deep Brain Stimulation Personalizing Therapy Based on Parkinsonian State.
Case Report: Chronic Adaptive Deep Brain Stimulation Personalizing Therapy Based on Parkinsonian State.
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病例报告:基于帕金森氏症的慢性自适应深度脑刺激个性化疗法。
DOI:
10.3389/fnhum.2021.702961
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发表时间:
2021
影响因子:
2.9
通讯作者:
Hattori N
中科院分区:
文献类型:
--
作者:
Nakajima A;Shimo Y;Fuse A;Tokugawa J;Hishii M;Iwamuro H;Umemura A;Hattori N
We describe the case of a 51-year-old man with Parkinson's disease (PD) presenting with motor fluctuations, who received bilateral subthalamic deep brain stimulation (DBS) with an adaptive DBS (aDBS) device, Percept™ PC (Medtronic, Inc. , Minneapolis, MN). This device can deliver electrical stimulations based on fluctuations of neural oscillations of the local field potential (LFP) at the target structure. We observed that the LFP fluctuations were less evident inside the hospital than outside, while the stimulation successfully adapted to beta oscillation fluctuations during the aDBS phase without any stimulation-induced side effects. Thus, this new device facilitates condition-dependent stimulation; this new stimulation method is feasible and provides new insights into the pathophysiological mechanisms of PD.
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影响因子:
11.2
作者:
Little, Simon;Pogosyan, Alex;Neal, Spencer;Zavala, Baltazar;Zrinzo, Ludvic;Hariz, Marwan;Foltynie, Thomas;Limousin, Patricia;Ashkan, Keyoumars;FitzGerald, James;Green, Alexander L.;Aziz, Tipu Z.;Brown, Peter
通讯作者:
Brown, Peter
影响因子:
3.4
作者:
Kühn, AA;Kupsch, A;Brown, P
通讯作者:
Brown, P
DOI:
10.1073/pnas.1517629112
发表时间:
2015-11-03
影响因子:
11.1
作者:
Feingold, Joseph;Gibson, Daniel J.;Graybiel, Ann M.
通讯作者:
Graybiel, Ann M.
影响因子:
8.6
作者:
Urrestarazu, Elena;Iriarte, Jorge;Artieda, Julio
通讯作者:
Artieda, Julio
影响因子:
46.9
作者:
Gilron R;Little S;Perrone R;Wilt R;de Hemptinne C;Yaroshinsky MS;Racine CA;Wang SS;Ostrem JL;Larson PS;Wang DD;Galifianakis NB;Bledsoe IO;San Luciano M;Dawes HE;Worrell GA;Kremen V;Borton DA;Denison T;Starr PA
通讯作者:
Starr PA