Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza.
Influenza Vaccination Modifies Disease Severity Among Community-dwelling Adults Hospitalized With Influenza.
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DOI：
10.1093/cid/cix468
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发表时间：
2017-10-15
期刊：
影响因子：
--
通讯作者：
Chaves SS
中科院分区：
文献类型：
--
作者：
Arriola C;Garg S;Anderson EJ;Ryan PA;George A;Zansky SM;Bennett N;Reingold A;Bargsten M;Miller L;Yousey-Hindes K;Tatham L;Bohm SR;Lynfield R;Thomas A;Lindegren ML;Schaffner W;Fry AM;Chaves SS
我们调查了2013-14年期间因实验室确诊的流感住院的成年人中流感疫苗接种对疾病严重程度的影响，该季节疫苗病毒与流行的病毒抗原相似。我们分析了2013-14年流感季节的数据，并使用倾向评分匹配来解释年龄层（18-49岁，50-64岁和≥65岁）内的疫苗接种概率。死亡、重症监护室（ICU）入院、住院和ICU住院时间（LOS）是严重程度的结局指标。多变量逻辑回归和竞争风险模型用于比较接种疫苗和未接种疫苗患者之间的疾病严重程度，调整抗病毒治疗的时间和从发病到住院的时间。流感疫苗接种与18-49岁患者院内死亡几率降低相关（校正比值比[aOR] = 0.21; 95%置信区间[CI]，0.05 - 0.97），50-64岁（aOR = 0.48; 95% CI，0.24 - 0.97）和≥65岁（aOR = 0.39; 95% CI，0.17 - 0.66）。接种疫苗还减少了18-49岁患者的ICU入院率（aOR = 0.63; 95% CI，0.42 - 0.93）和≥65岁（aOR = 0.63; 95%CI，0.48至0.81），并缩短了50-64岁患者的ICU LOS（校正的相对危险度[aRH] = 1.36; 95% CI，1.06 - 1.74）和≥65岁（aRH = 1.34; 95% CI，1.06至1.73），以及50-64岁（aRH = 1.13; 95% CI，1.02至1.26）和≥65岁（aRH = 1.24; 95% CI，1.13至1.37）的医院LOS。2013-14流感季节期间的流感疫苗接种减轻了因实验室确诊流感住院的成年人的不良结局。
We investigated the effect of influenza vaccination on disease severity in adults hospitalized with laboratory-confirmed influenza during 2013–14, a season in which vaccine viruses were antigenically similar to those circulating. We analyzed data from the 2013–14 influenza season and used propensity score matching to account for the probability of vaccination within age strata (18–49, 50–64, and ≥65 years). Death, intensive care unit (ICU) admission, and hospital and ICU lengths of stay (LOS) were outcome measures for severity. Multivariable logistic regression and competing risk models were used to compare disease severity between vaccinated and unvaccinated patients, adjusting for timing of antiviral treatment and time from illness onset to hospitalization. Influenza vaccination was associated with a reduction in the odds of in-hospital death among patients aged 18–49 years (adjusted odds ratios [aOR] = 0.21; 95% confidence interval [CI], 0.05 to 0.97), 50–64 years (aOR = 0.48; 95% CI, 0.24 to 0.97), and ≥65 years (aOR = 0.39; 95% CI, 0.17 to 0.66). Vaccination also reduced ICU admission among patients aged 18–49 years (aOR = 0.63; 95% CI, 0.42 to 0.93) and ≥65 years (aOR = 0.63; 95% CI, 0.48 to 0.81), and shortened ICU LOS among those 50–64 years (adjusted relative hazards [aRH] = 1.36; 95% CI, 1.06 to 1.74) and ≥65 years (aRH = 1.34; 95% CI, 1.06 to 1.73), and hospital LOS among 50–64 years (aRH = 1.13; 95% CI, 1.02 to 1.26) and ≥65 years (aRH = 1.24; 95% CI, 1.13 to 1.37). Influenza vaccination during 2013–14 influenza season attenuated adverse outcome among adults that were hospitalized with laboratory-confirmed influenza.
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影响因子：
11.8
作者：
Chaves SS;Lynfield R;Lindegren ML;Bresee J;Finelli L
通讯作者：
Finelli L
DOI：
10.1001/jama.2015.12160
发表时间：
2015-10-13
期刊：
JAMA
影响因子：
--
作者：
Grijalva CG;Zhu Y;Williams DJ;Self WH;Ampofo K;Pavia AT;Stockmann CR;McCullers J;Arnold SR;Wunderink RG;Anderson EJ;Lindstrom S;Fry AM;Foppa IM;Finelli L;Bramley AM;Jain S;Griffin MR;Edwards KM
通讯作者：
Edwards KM
DOI：
10.1093/cid/civ084
发表时间：
2015-05-01
期刊：
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
影响因子：
--
作者：
O'Hagan JJ;Wong KK;Campbell AP;Patel A;Swerdlow DL;Fry AM;Koonin LM;Meltzer MI
通讯作者：
Meltzer MI
影响因子：
6.4
作者：
Flannery, Brendan;Zimmerman, Richard K.;Fry, Alicia M.
通讯作者：
Fry, Alicia M.
影响因子：
6.4
作者：
Arriola, Carmen S.;Anderson, Evan J.;Chaves, Sandra S.
通讯作者：
Chaves, Sandra S.