Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants.
Increase in SARS-CoV-2 Seroprevalence in UK Domestic Felids Despite Weak Immunogenicity of Post-Omicron Variants.
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DOI：
10.3390/v15081661
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发表时间：
2023-07-30
期刊：
影响因子：
--
通讯作者：
Hosie MJ
中科院分区：
文献类型：
--
作者：
Tyson GB;Jones S;Montreuil-Spencer C;Logan N;Scott S;Sasvari H;McDonald M;Marshall L;Murcia PR;Willett BJ;Weir W;Hosie MJ
在整个COVID-19大流行期间，家猫的SARS-CoV-2感染引起了对动物健康和物种间传播潜力的担忧。已知猫易受Omicron变体及其后代的影响，然而，猫对这些变体的免疫反应尚未明确。我们的目的是估计目前SARS-CoV-2在英国宠物猫中的血清阳性率，以及对Omicron（BA.1）变体的中和抗体反应。观察到中和血清阳性率为4.4%，总体血清阳性率为13.9%。研究发现，纯种猫和公猫以及年龄在2至5岁之间的猫的血清阳性率最高。发现Omicron变体在猫中的免疫原性低于B.1、Alpha和Delta变体，这反映了先前关于人类免疫和疫苗逃避的报告。这些结果进一步强调了随着病毒不断演变，监测英国猫的SARS-CoV-2感染的重要性。
Throughout the COVID-19 pandemic, SARS-CoV-2 infections in domestic cats have caused concern for both animal health and the potential for inter-species transmission. Cats are known to be susceptible to the Omicron variant and its descendants, however, the feline immune response to these variants is not well defined. We aimed to estimate the current seroprevalence of SARS-CoV-2 in UK pet cats, as well as characterise the neutralising antibody response to the Omicron (BA.1) variant. A neutralising seroprevalence of 4.4% and an overall seroprevalence of 13.9% was observed. Both purebred and male cats were found to have the highest levels of seroprevalence, as well as cats aged between two and five years. The Omicron variant was found to have a lower immunogenicity in cats than the B.1, Alpha and Delta variants, which reflects previous reports of immune and vaccine evasion in humans. These results further underline the importance of surveillance of SARS-CoV-2 infections in UK cats as the virus continues to evolve.
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影响因子：
13.2
作者：
Ai J;Zhang H;Zhang Y;Lin K;Zhang Y;Wu J;Wan Y;Huang Y;Song J;Fu Z;Wang H;Guo J;Jiang N;Fan M;Zhou Y;Zhao Y;Zhang Q;Liu Q;Lv J;Li P;Qiu C;Zhang W
通讯作者：
Zhang W
影响因子：
11.1
作者：
Akerman, Anouschka;Milogiannakis, Vanessa;Jean, Tyra;Esneau, Camille;Silva, Mariana Ruiz;Ison, Timothy;Fichter, Christina;Lopez, Joseph A.;Chandra, Deborah;Naing, Zin;Caguicla, Joanna;Li, Daiyang;Walker, Gregory;Amatayakul-Chantler, Supavadee;Roth, Nathan;Manni, Sandro;Hauser, Thomas;Barnes, Thomas;Condylios, Anna;Yeang, Malinna;Wong, Maureen;Foster, Charles S. P.;Sato, Kenta;Lee, Sharon;Song, Yang;Mao, Lijun;Sigmund, Allison;Phu, Amy;Vande More, Ann Marie;Hunt, Stephanie;Douglas, Mark;Caterson, Ian;Britton, Warwick;Sandgren, Kerrie;Bull, Rowena;Lloyd, Andrew;Triccas, Jamie;Tangye, Stuart;Bartlett, Nathan W.;Darley, David;Matthews, Gail;Stark, Damien J.;Petoumenos, Kathy;Rawlinson, William D.;Murrell, Ben;Brilot, Fabienne;Cunningham, Anthony L.;Kelleher, Anthony D.;Aggarwal, Anupriya;Turville, Stuart G.
通讯作者：
Turville, Stuart G.
DOI：
10.3390/v12091011
发表时间：
2020-09-10
期刊：
Viruses
影响因子：
--
作者：
Hyseni I;Molesti E;Benincasa L;Piu P;Casa E;Temperton NJ;Manenti A;Montomoli E
通讯作者：
Montomoli E
影响因子：
11.8
作者：
Colitti B;Bertolotti L;Mannelli A;Ferrara G;Vercelli A;Grassi A;Trentin C;Paltrinieri S;Nogarol C;Decaro N;Brocchi E;Rosati S
通讯作者：
Rosati S
影响因子：
3.2
作者：
Chetboul V;Foulex P;Kartout K;Klein AM;Sailleau C;Dumarest M;Delaplace M;Gouilh MA;Mortier J;Le Poder S
通讯作者：
Le Poder S