Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy.
Multifunctional biomaterial platforms for blocking the fibrosis process and promoting cellular restoring effects in myocardial fibrosis therapy.
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心肌纤维化治疗中阻断纤维化过程并促进细胞恢复作用的多功能生物材料平台
DOI：
10.3389/fbioe.2022.988683
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发表时间：
2022
影响因子：
5.7
通讯作者：
Hou, Jun
中科院分区：
文献类型：
--
作者：
Yue, Tian;Xiong, Shiqiang;Zheng, Dezhi;Wang, Yi;Long, Pan;Yang, Jiali;Danzeng, Dunzhu;Gao, Han;Wen, Xudong;Li, Xin;Hou, Jun
心肌纤维化是急性和慢性心肌损伤后不正常愈合的结果，是心力衰竭和心功能不全的直接原因。临床方法是通过疏通血管的手术来保持心脏功能和抑制纤维化。然而，这种策略并不能充分解决纤维化恶化和心功能恢复的问题。因此，开发了许多生物材料平台来解决上述问题。本文综述了现有的生物材料递送和修复平台，并阐明了基于生物材料平台的治疗策略，包括阻断纤维化过程的一般策略和促进细胞修复效果的新策略。心肌纤维化的主要研究方向应该是能够阻断进一步纤维化进展和促进心肌细胞活力的结构的发展，而重建正常心功能所需的结构是心肌纤维化治疗的核心。最后，对生物材料在心肌纤维化中的应用前景进行了展望。
Myocardial fibrosis is the result of abnormal healing after acute and chronic myocardial damage and is a direct cause of heart failure and cardiac insufficiency. The clinical approach is to preserve cardiac function and inhibit fibrosis through surgery aimed at dredging blood vessels. However, this strategy does not adequately address the deterioration of fibrosis and cardiac function recovery. Therefore, numerous biomaterial platforms have been developed to address the above issues. In this review, we summarize the existing biomaterial delivery and restoring platforms, In addition, we also clarify the therapeutic strategies based on biomaterial platforms, including general strategies to block the fibrosis process and new strategies to promote cellular restoring effects. The development of structures with the ability to block further fibrosis progression as well as to promote cardiomyocytes viability should be the main research interests in myocardial fibrosis, and the reestablishment of structures necessary for normal cardiac function is central to the treatment of myocardial fibrosis. Finally, the future application of biomaterials for myocardial fibrosis is also highlighted.
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影响因子：
14
作者：
Awada HK;Long DW;Wang Z;Hwang MP;Kim K;Wang Y
通讯作者：
Wang Y
影响因子：
14
作者：
Dorsey SM;McGarvey JR;Wang H;Nikou A;Arama L;Koomalsingh KJ;Kondo N;Gorman JH 3rd;Pilla JJ;Gorman RC;Wenk JF;Burdick JA
通讯作者：
Burdick JA
DOI：
10.2147/ccid.s50046
发表时间：
2014
期刊：
Clinical, cosmetic and investigational dermatology
影响因子：
--
作者：
Darby IA;Laverdet B;Bonté F;Desmoulière A
通讯作者：
Desmoulière A
影响因子：
14
作者：
Bao, Rui;Tan, Baoyu;Liu, Wenguang
通讯作者：
Liu, Wenguang
影响因子：
16.6
作者：
Carlini, Andrea S.;Gaetani, Roberto;Gianneschi, Nathan C.
通讯作者：
Gianneschi, Nathan C.