N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections.
N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections.
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DOI：
10.1021/acschembio.0c00314
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发表时间：
2020-07-17
影响因子：
4
通讯作者：
Lin H
中科院分区：
文献类型：
--
作者：
Kosciuk T;Lin H
蛋白肉豆蔻酰基化，即添加一个14碳饱和酰基，是一种丰富的修饰，涉及多种生物事件，如发育、免疫、肿瘤发生和感染。n -肉豆蔻酰基转移酶（NMT）是催化这种修饰的酶。许多优雅的研究已经建立了指导催化的规则，包括必需的n端甘氨酸对底物氨基酸序列的要求，以及共同翻译的作用模式。脂肪酸类似物、小分子抑制剂和新的蛋白质组学策略等技术的最新进展，使人们能够更深入地了解NMT的活性和功能。在这里，我们重点讨论最近的研究表明NMT也是一种赖氨酸肉豆芽酰基转移酶，该酶通过以前未被注意到的溶剂通道进行调节，以及蛋白质-蛋白质相互作用调节NMT的机制。我们还总结了NMT在癌症、免疫和感染中的作用的最新发现，以及肉豆蔻酰化的药理学靶向进展。我们的分析强调了进一步理解和发现的机会。
Protein myristoylation, the addition of a 14-carbon saturated acyl group, is an abundant modification implicated in biological events as diverse as development, immunity, oncogenesis, and infections. N-myristoyltransferase (NMT) is the enzyme that catalyzes this modification. Many elegant studies have established the rules guiding the catalysis including substrate amino acid sequence requirement with the indispensable N-terminal glycine, and a co-translational mode of action. Recent advances in technology such as the development of fatty acid analogs, small molecule inhibitors, and new proteomic strategies, allowed a deeper insight into the NMT activity and function. Here we focus on discussing recent work demonstrating NMT as also a lysine myristoyltransferase, the enzyme’s regulation by a previously unnoticed solvent channel, and mechanism of NMT regulation by protein-protein interactions. We also summarize recent findings of NMT’s role in cancer, immunity and infections, and the advances in pharmacological targeting of myristoylation. Our analyses highlight opportunities for further understanding and discoveries.
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影响因子：
16.6
作者：
Dian, Cyril;Perez-Dorado, Inmaculada;Giglione, Carmela
通讯作者：
Giglione, Carmela
DOI：
10.1002/art.40504
发表时间：
2018-07
期刊：
Arthritis & rheumatology (Hoboken, N.J.)
影响因子：
--
作者：
Falconer J;Murphy AN;Young SP;Clark AR;Tiziani S;Guma M;Buckley CD
通讯作者：
Buckley CD
影响因子：
7.3
作者：
Harrison JR;Brand S;Smith V;Robinson DA;Thompson S;Smith A;Davies K;Mok N;Torrie LS;Collie I;Hallyburton I;Norval S;Simeons FRC;Stojanovski L;Frearson JA;Brenk R;Wyatt PG;Gilbert IH;Read KD
通讯作者：
Read KD
影响因子：
4
作者：
Fang, Wenxia;Robinson, David A.;Raimi, Olawale G.;Blair, David E.;Harrison, Justin R.;Lockhart, Deborah E. A.;Torrie, Leah S.;Ruda, Gian Filippo;Wyatt, Paul G.;Gilbert, Ian H.;van Aalten, Daan M. F.
通讯作者：
van Aalten, Daan M. F.
影响因子：
32.4
作者：
Deftos, ML;Huang, E;Bevan, MJ
通讯作者：
Bevan, MJ