Differential involvement of the basolateral amygdala and orbitofrontal cortex in the formation of sensory-specific associations in conditioned flavor preference and magazine approach paradigms.
Differential involvement of the basolateral amygdala and orbitofrontal cortex in the formation of sensory-specific associations in conditioned flavor preference and magazine approach paradigms.
复制标题
DOI：
10.1111/j.1460-9568.2012.08113.x
复制
发表时间：
2012-06
期刊：
影响因子：
--
通讯作者：
Wheeler DS
中科院分区：
文献类型：
--
作者：
Scarlet J;Delamater AR;Campese V;Fein M;Wheeler DS
四个实验研究的作用，基底外侧杏仁核和眶额皮层的形成中的感觉特异性协会的条件性风味偏好和条件杂志的方法范式，使用美国贬值和选择性巴甫洛夫仪器传输程序在Long Evans大鼠。实验1发现，训练前杏仁核和眶额皮质病变没有检测到的影响，形成或灵活使用的感官特异性风味营养协会在美国贬值任务，风味线索配对同时或顺序与营养奖励在缺水的科目。在实验2中，训练前杏仁核和眶额皮质病变都减弱了结果特异性巴甫洛夫工具转移。实验3表明，杏仁核病变没有影响形成的感官特异性风味营养协会在美国贬值任务中的食物剥夺的科目。最后，实验4表明，实验3中使用的结果是足够的动机显着支持条件性口味偏好。这些研究结果表明，虽然眶额皮质和杏仁核病变减弱收购的感觉特异性协会在杂志的方法条件反射，没有病变的能力，适当地回应一个味道提示，是一个贬值的结果。
Four experiments examined the roles of the basolateral amygdala and orbitofrontal cortex in the formation of sensory-specific associations in conditioned flavor preference and conditioned magazine approach paradigms using US devaluation and selective Pavlovian-instrumental transfer procedures in Long Evans rats. Experiment 1 found that pre-training amygdala and orbitofrontal cortex lesions had no detectable effect on the formation or flexible use of sensory-specific flavor-nutrient associations in a US devaluation task, where flavor cues were paired either simultaneously or sequentially with nutrient rewards in water-deprived subjects. In Experiment 2, pre-training amygdala and orbitofrontal cortex lesions both attenuated outcome-specific Pavlovian-instrumental transfer. Experiment 3 indicated that amygdala lesions have no effect on the formation of sensory-specific flavor-nutrient associations in a US devaluation task in food-deprived subjects. Finally, Experiment 4 demonstrated that the outcomes used in Experiment 3 were sufficiently motivationally significant to support conditioned flavor preference. These findings suggest that although both orbitofrontal cortex and amygdala lesions attenuate the acquisition of sensory-specific associations in magazine approach conditioning, neither lesion reduces the ability to appropriately respond to a flavor cue that was paired with a devalued outcome.
登录
查看更多内容
影响因子：
2.7
作者：
Dwyer, Dominic M.
通讯作者：
Dwyer, Dominic M.
DOI：
10.1523/jneurosci.3758-08.2009
发表时间：
2009-01-21
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Johnson AW;Gallagher M;Holland PC
通讯作者：
Holland PC
影响因子：
5.3
作者：
Ostlund, Sean B.;Balleine, Bernard W.
通讯作者：
Balleine, Bernard W.
影响因子：
5.3
作者：
Dwyer, Dominic M.;Killcross, Simon
通讯作者：
Killcross, Simon
影响因子：
5.4
作者：
Pavlov, IP
通讯作者：
Pavlov, IP