Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.
Exercise to Mend Aged-tissue Crosstalk in Bone Targeting Osteoporosis & Osteoarthritis.
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DOI：
10.1016/j.semcdb.2021.08.011
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发表时间：
2022-03
影响因子：
7.3
通讯作者：
Styner M
中科院分区：
文献类型：
--
作者：
Little-Letsinger SE;Rubin J;Diekman B;Rubin CT;McGrath C;Pagnotti GM;Klett EL;Styner M
衰老通过多种过程引起骨结构和强度的改变，加剧常见的与衰老相关的疾病，如骨质疏松症和骨关节炎。衰老的细胞标志进行了检查，与骨和骨髓微环境，以及这些可能有助于成骨细胞，骨细胞，骨髓脂肪细胞，软骨细胞，破骨细胞及其各自的祖细胞中的各种年龄相关的扰动的方式。细胞衰老、干细胞衰竭、线粒体功能障碍、表观遗传和细胞内通讯变化是衰老的中心途径，被认为与衰老相关并可能是衰老的原因。我们专注于这些在肌肉骨骼系统和突出的知识差距，在文献中关于细胞和组织串扰骨，软骨和骨髓龛。虽然senolytics已被用于靶向衰老途径，在这里，我们提出了非药理学，运动为基础的干预措施作为前瞻性的“senolytics”对骨骼的衰老影响。增加骨量和延迟骨质疏松症和骨关节炎的发作或进展是整个生命周期定期锻炼的一些公认的好处。需要进一步的研究来描述衰老的细胞指标如何在骨骼和骨髓龛中表现出来，以及改变的细胞和组织串扰如何影响疾病的进展，以及考虑将运动作为一种治疗方式，作为一种手段来增强骨靶向治疗的发现。
Aging induces alterations in bone structure and strength through a multitude of processes, exacerbating common aging- related diseases like osteoporosis and osteoarthritis. Cellular hallmarks of aging are examined, as related to bone and the marrow microenvironment, and ways in which these might contribute to a variety of age-related perturbations in osteoblasts, osteocytes, marrow adipocytes, chondrocytes, osteoclasts, and their respective progenitors. Cellular senescence, stem cell exhaustion, mitochondrial dysfunction, epigenetic and intracellular communication changes are central pathways and recognized as associated and potentially causal in aging. We focus on these in musculoskeletal system and highlight knowledge gaps in the literature regarding cellular and tissue crosstalk in bone, cartilage, and the bone marrow niche. While senolytics have been utilized to target aging pathways, here we propose non-pharmacologic, exercise-based interventions as prospective “senolytics” against aging effects on the skeleton. Increased bone mass and delayed onset or progression of osteoporosis and osteoarthritis are some of the recognized benefits of regular exercise across the lifespan. Further investigation is needed to delineate how cellular indicators of aging manifest in bone and the marrow niche and how altered cellular and tissue crosstalk impact disease progression, as well as consideration of exercise as a therapeutic modality, as a means to enhance discovery of bone-targeted therapies.
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影响因子：
29
作者：
Ambrogini E;Almeida M;Martin-Millan M;Paik JH;Depinho RA;Han L;Goellner J;Weinstein RS;Jilka RL;O'Brien CA;Manolagas SC
通讯作者：
Manolagas SC
影响因子：
4.8
作者：
Baker, J. M.;De Lisio, Michael;Parise, Gianni
通讯作者：
Parise, Gianni
影响因子：
4.8
作者：
Artsi, Hanna;Cohen-Kfir, Einav;Dresner-Pollak, Rivka
通讯作者：
Dresner-Pollak, Rivka
DOI：
10.1073/pnas.1036475100
发表时间：
2003-05-13
影响因子：
11.1
作者：
Bonyadi, M;Waldman, SD;Stanford, WL
通讯作者：
Stanford, WL
影响因子：
4
作者：
Bernhard, A.;Milovanovic, P.;Busse, B.
通讯作者：
Busse, B.