A meta-analysis of P2X7 gene-762T/C polymorphism and pulmonary tuberculosis susceptibility.
A meta-analysis of P2X7 gene-762T/C polymorphism and pulmonary tuberculosis susceptibility.
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P2X7基因762T/C多态性与肺结核易感性的Meta分析
DOI：
10.1371/journal.pone.0096359
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Zhen G
中科院分区：
文献类型：
--
作者：
Yi L;Cheng D;Shi H;Huo X;Zhang K;Zhen G
我们进行了一项综合的荟萃分析，以确定P2X7 -762T/C多态性与肺结核易感性之间的关联。
基于对PubMed、SCI、爱思唯尔、中国知网（CNKI）和万方数据库的全面检索，我们确定了关于P2X7 -762T/C多态性与肺结核风险之间关联的符合条件的研究。在随机效应模型中计算了合并优势比（ORs）和95%置信区间（95%CIs）。
这项荟萃分析共纳入了8项病例对照研究中的2207例肺结核病例和2220例对照。等位基因模型（C与T：p = 0.15；OR = 0.83，95%CI = 0.65 - 1.07）、纯合子模型（CC与TT：p = 0.23；OR = 0.73，95%CI = 0.44 - 1.22）以及杂合子模型（CT与TT：p = 0.57；OR = 0.92，95%CI = 0.68 - 1.24）均未显示出患肺结核的风险增加。同样，显性模型（CC + CT与TT：p = 0.32；OR = 0.84，95%CI = 0.59 - 1.19）和隐性模型（CC与CT + TT：p = 0.08；OR = 0.77，95%CI = 0.57 - 1.04）也未能显示出患肺结核的风险增加。按种族进行的亚组分析未检测到P2X7 -762T/C多态性与肺结核易感性之间存在任何显著关联。
P2X7 -762T/C基因多态性与肺结核易感性无关。
Aim We performed a comprehensive meta-analysis to determine the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis susceptibility. Methodology Based on comprehensive searches of the PubMed, SCI, Elsevier, China National Knowledge Infrastructure (CNKI) and Wanfang Database, we identified eligible studies about the association between P2X7 -762T/C polymorphism and pulmonary tuberculosis risk. Pooled odds ratio (ORs) and 95% confidence intervals (95%CIs) were calculated in random-effects model. Results A total of 2207 tuberculosis cases and 2220 controls in 8 case-control studies were included in this meta-analysis. Allele model (C vs. T: p = 0.15; OR = 0.83, 95% CI = 0.65–1.07), homozygous model (CC vs. TT: p = 0.23; OR = 0.73, 95% CI = 0.44 to 1.22), and heterozygous model (CT vs. TT: p = 0.57; OR = 0.92, 95% CI = 0.68 to 1.24) did not show increased risk of developing pulmonary tuberculosis. Similarly, dominant model (CC+CT vs. TT: p = 0.32; OR = 0.84, 95% CI = 0.59 to 1.19) and recessive model (CC vs. CT+TT: p = 0.08; OR = 0.77, 95% CI = 0.57 to 1.04) failed to show increased risk of developing pulmonary tuberculosis. Subgroup analysis by ethnicity did not detect any significant association between P2X7–762T/C polymorphism and pulmonary tuberculosis susceptibility. Conclusions P2X7 -762T/C gene polymorphism is not associated with pulmonary tuberculosis susceptibility.
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