Design and mechanical evaluation of a novel fiber-reinforced scaffold for meniscus replacement.
Design and mechanical evaluation of a novel fiber-reinforced scaffold for meniscus replacement.
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DOI：
10.1002/jbm.a.33260
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发表时间：
2012-01
影响因子：
4.9
通讯作者：
Dunn, Michael G.
中科院分区：
文献类型：
--
作者：
Balint, Eric;Gatt, Charles J., Jr.;Dunn, Michael G.
设计、制作了一种纤维增强可降解半月板组织替代支架，并对其进行了力学性能评价。假设1)纤维网络设计将通过产生环向拉伸载荷来分担部分压缩载荷，以及2)支架的拉伸性能将类似于半月板的拉伸性能。两种不同纤维含量的半月板支架设计(1000或500纤维：MS1000，MS500)接受高达100N和250N的循环压缩载荷，并测量前后锚定的综合拉伸载荷。还对每个装置和绵羊半月板进行了标准拉伸测试。两种支架产生的拉伸载荷与施加的压缩载荷成正比，MS1000支架产生的拉伸载荷大约是MS500支架的两倍。MS1000支架的拉伸强度显著高于绵羊内侧和外侧半月板，约为MS500支架的两倍。MS1000支架的刚度低于外侧半月板，但与内侧半月板无统计学差异。这些结果支持了我们的假设，即这种新型的纤维增强支架可以模拟压缩载荷下正常半月板组织的拉伸和环状应力行为。对于半月板置换装置来说，环向拉伸强度和刚度是合适的。
A fiber-reinforced degradable scaffold for replacement of meniscal tissue was designed, fabricated, and mechanically evaluated. The hypotheses were that 1) the fiber network design would share a portion of compressive loads via the generation of circumferential tensile loads, and 2) the scaffold tensile properties would be similar to those of the meniscus. Two meniscus scaffold designs varying in fiber content (1,000 or 500 fibers: MS1000, MS500) underwent cyclic compressive loading up to 100N and 250N, with resultant tensile loads measured at the anterior and posterior anchors. Standard tensile testing was also performed on each device and ovine menisci. Both scaffolds generated tensile loads directly proportional to the applied compressive loads, with MS1000 scaffolds generating approximately twice the tensile loads of MS500 scaffolds. The tensile strength of MS1000 scaffolds was significantly higher than that of the medial and lateral ovine menisci, and approximately twice that of the MS500 scaffolds. The stiffness of MS1000 scaffolds was lower than that of the lateral meniscus, but not statistically different from that of the medial meniscus. These results support our hypotheses that this novel fiber-reinforced scaffold can mimic the tensile and hoop stress behavior of normal meniscal tissue under compressive loading. The circumferential tensile strength and stiffness are appropriate for a meniscus replacement device.
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DOI：
10.1002/jbm.820291107
发表时间：
1995-11-01
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
--
作者：
DUNN, MG;LIESCH, JB;ZAWADSKY, JP
通讯作者：
ZAWADSKY, JP
DOI：
10.1115/1.3138409
发表时间：
1983-01-01
影响因子：
1.7
作者：
AHMED, AM;BURKE, DL
通讯作者：
BURKE, DL
影响因子：
2.8
作者：
BYLSKIAUSTROW, DI;MALUMED, J;GROOD, ES
通讯作者：
GROOD, ES
DOI：
10.1097/00005373-197002000-00008
发表时间：
1970-01-01
期刊：
JOURNAL OF TRAUMA
影响因子：
--
作者：
RADIN, EL;BRYAN, RS
通讯作者：
BRYAN, RS
影响因子：
4.9
作者：
Kang, Sun-Woong;Son, Sun-Mi;Kim, Byung-Soo
通讯作者：
Kim, Byung-Soo