A quantitative comparison of NIRS and fMRI across multiple cognitive tasks.
A quantitative comparison of NIRS and fMRI across multiple cognitive tasks.
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DOI：
10.1016/j.neuroimage.2010.10.069
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发表时间：
2011-02-14
期刊：
影响因子：
5.7
通讯作者：
Reiss AL
中科院分区：
文献类型：
--
作者：
Cui X;Bray S;Bryant DM;Glover GH;Reiss AL
近红外光谱（NIRS）是一种越来越受欢迎的研究大脑功能的技术。NIRS相对于功能性磁共振成像（fMRI）有几个优点，如测量氧合和脱氧血红蛋白的浓度变化，更好的时间分辨率，易于管理，以及缺点，最突出的是较差的空间分辨率和降低的信噪比（SNR）。虽然fMRI已经成为人体大脑活体成像的黄金标准，但在实践中，NIRS是一种比fMRI更方便、更便宜的技术。因此，许多研究人员感兴趣的是如何将NIRS与fMRI在脑功能研究中进行比较。在本研究中，我们同时扫描了参与者的近红外光谱和功能磁共振成像的认知任务电池，放置近红外光谱探头在额叶和顶叶的大脑区域。我们在时间域和空间域对信号进行了详细比较。我们发现，近红外光谱信号有显着较弱的SNR，但仍然经常与功能磁共振成像测量高度相关。SNR和头皮与大脑之间的距离都有助于NIRS/fMRI相关性的变化。在空间域中，我们发现，光子路径形成一个椭圆之间的近红外发射器和检测器与BOLD响应最强的相关性。总之，这些发现表明，虽然NIRS可以作为fMRI的适当替代品，用于研究与认知任务相关的大脑活动，但在设计NIRS研究时应注意确保：1）空间分辨率足以回答感兴趣的问题，2）设计考虑到较弱的SNR，特别是在远离头皮的大脑区域。
Near infrared spectroscopy (NIRS) is an increasingly popular technology for studying brain function. NIRS presents several advantages relative to functional magnetic resonance imaging (fMRI), such as measurement of concentration changes in both oxygenated- and deoxygenated hemoglobin, finer temporal resolution, and ease of administration, as well as disadvantages, most prominently inferior spatial resolution and decreased signal-to-noise ratio (SNR). While fMRI has become the gold standard for in vivo imaging of the human brain, in practice NIRS is a more convenient and less expensive technology than fMRI. It is therefore of interest to many researchers how NIRS compares to fMRI in studies of brain function. In the present study we scanned participants with simultaneous NIRS and fMRI on a battery of cognitive tasks, placing NIRS probes over both frontal and parietal brain regions. We performed detailed comparisons of the signals in both temporal and spatial domains. We found that NIRS signals have significantly weaker SNR, but are nonetheless often highly correlated with fMRI measurements. Both SNR and the distance between the scalp and the brain contributed to variability in the NIRS/fMRI correlations. In the spatial domain, we found that a photon path forming an ellipse between the NIRS emitter and detector correlated most strongly with the BOLD response. Taken together these findings suggest that, while NIRS can be an appropriate substitute for fMRI for studying brain activity related to cognitive tasks, care should be taken when designing studies with NIRS to ensure that: 1) the spatial resolution is adequate for answering the question of interest and 2) the design accounts for weaker SNR, especially in brain regions more distal from the scalp.
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影响因子：
2.6
作者：
Herrmann, MJ;Ehlis, AC;Fallgatter, AJ
通讯作者：
Fallgatter, AJ
DOI：
10.1073/pnas.94.26.14826
发表时间：
1997-12-23
影响因子：
11.1
作者：
Malonek, D;Dirnagl, U;Grinvald, A
通讯作者：
Grinvald, A
影响因子：
5.7
作者：
Hoge, RD;Franceschini, MA;Boas, DA
通讯作者：
Boas, DA
影响因子：
3.2
作者：
Coyle, S;Ward, T;McDarby, G
通讯作者：
McDarby, G
影响因子：
4
作者：
Coyle, Shirley M.;Ward, Tomas E.;Markham, Charles M.
通讯作者：
Markham, Charles M.