Modulation of tight junction structure and function by kinases and phosphatases targeting occludin.
Modulation of tight junction structure and function by kinases and phosphatases targeting occludin.
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DOI：
10.1155/2012/807356
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发表时间：
2012
影响因子：
--
通讯作者：
Huber O
中科院分区：
文献类型：
--
作者：
Dörfel MJ;Huber O
紧密连接 (TJ) 通常代表上皮细胞和内皮细胞层中最顶端的接触，在细胞外或管腔空间与体内底层组织的分离中发挥着重要作用。根据蛋白质组成，TJ 定义了屏障特性，此外还维持细胞极性。整合膜蛋白的两个主要家族形成了典型的 TJ 链网络，即紧密连接相关的 MARVEL 蛋白 (TAMP) 家族成员 occludin、tricellulin 和 MarvelD3 以及一组特定的claudins。 Occludin 是这些四跨膜蛋白中第一个被识别的成员，现在被广泛认为是 TJ 组装和功能的调节剂。因此，occludin本身必须受到严格监管。在这种情况下，occludin 的磷酸化似乎至关重要。在这里，我们想总结一下目前关于直接修饰 occludin 的激酶和磷酸酶的知识，以及它们在 TJ 结构、功能和动力学调节中的作用。
Tight junctions (TJs) typically represent the most apical contacts in epithelial and endothelial cell layers where they play an essential role in the separation of extracellular or luminal spaces from underlying tissues in the body. Depending on the protein composition, TJs define the barrier characteristics and in addition maintain cell polarity. Two major families of integral membrane proteins form the typical TJ strand network, the tight junction-associated MARVEL protein (TAMP) family members occludin, tricellulin, and MarvelD3 as well as a specific set of claudins. Occludin was the first identified member of these tetraspanins and is now widely accepted as a regulator of TJ assembly and function. Therefore, occludin itself has to be tightly regulated. Phosphorylation of occludin appears to be of central importance in this context. Here we want to summarize current knowledge on the kinases and phosphatases directly modifying occludin, and their role in the regulation of TJ structure, function, and dynamics.
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影响因子：
2.9
作者：
Amano, Mutsuki;Nakayama, Masanori;Kaibuchi, Kozo
通讯作者：
Kaibuchi, Kozo
影响因子：
3.4
作者：
Capaldo, Christopher T.;Nusrat, Asma
通讯作者：
Nusrat, Asma
紧密连接蛋白 Occludin 调节上皮细胞的定向迁移。
影响因子：
11.8
作者：
Du, Dan;Xu, Feilai;Chen, Zhengjun
通讯作者：
Chen, Zhengjun
影响因子：
4.1
作者：
Basuroy, S;Seth, A;Rao, R
通讯作者：
Rao, R
单个基因产物Claudin -1或-2，在成纤维细胞中重构紧密结合的连接链和新兵。
影响因子：
7.8
作者：
Furuse, M;Sasaki, H;Fujimoto, K;Tsukita, S
通讯作者：
Tsukita, S