Lack of insula reactivity to aversive stimuli in schizophrenia.
Lack of insula reactivity to aversive stimuli in schizophrenia.
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DOI：
10.1016/j.schres.2012.10.038
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发表时间：
2013-01
影响因子：
4.5
通讯作者：
Holt DJ
中科院分区：
文献类型：
--
作者：
Linnman C;Coombs G 3rd;Goff DC;Holt DJ
根据疼痛不敏感的临床报告和最近的神经影像学发现，精神分裂症患者可能已经改变了痛觉。在这里，我们使用功能磁共振成像和经典条件反射范式（包括将电击与中性照片配对）检查了神经对厌恶电刺激的反应和对这种刺激的即时预期。15名精神分裂症患者和13名健康男性在人口学特征、电刺激水平和扫描运动方面相匹配。两组的中脑、丘脑、扣带回、脑岛和体感觉皮层均出现了强烈的反应。然而，与对照组相比，精神分裂症患者中岛的激活明显降低（pFWE = 0.002， T=5.72，簇大小=24体素）。此外，精神分裂症组脑岛反应性的缺乏可以通过阳性症状的程度来预测（r = - 0.46, p=0.04）。相比之下，两组在预期电击时的神经反应程度上没有显著差异。这些发现为精神分裂症患者存在基本的内感受知觉缺陷提供了支持，这可能在精神病状态的产生和/或维持中发挥作用。
Patients with schizophrenia may have altered pain perception, as suggested by clinical reports of pain insensitivity, and recent neuroimaging findings. Here, we examined neural responses to an aversive electrical stimulus and the immediate anticipation of such a stimulus using fMRI and a classical conditioning paradigm, which involved pairing an electrical shock with a neutral photograph. Fifteen men with schizophrenia and 13 healthy men, matched for demographic characteristics, electrical stimulation level and scan movement, were studied. The shock induced robust responses in midbrain, thalamus, cingulate gyrus, insula and somatosensory cortex in both groups. However, compared to controls, the schizophrenic patients displayed significantly lower activation of the middle insula (pFWE = 0.002, T=5.72, cluster size =24 voxels). Moreover, the lack of insula reactivity in the schizophrenia group was predicted by the magnitude of positive symptoms (r = −0.46, p=0.04). In contrast, there were no significant differences between the two groups in the magnitude of neural responses during anticipation of the shock. These findings provide support for the existence of a basic deficit in interoceptive perception in schizophrenia, which could play a role in the generation and/or maintenance of psychotic states.
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影响因子：
11.2
作者：
BERTHIER, M;STARKSTEIN, S;LEIGUARDA, R
通讯作者：
LEIGUARDA, R
影响因子：
4.5
作者：
Crespo-Facorro, B;Kim, JJ;Magnotta, V
通讯作者：
Magnotta, V
影响因子：
5.3
作者：
Karnath, HO;Baier, B;Nägele, T
通讯作者：
Nägele, T
影响因子：
2.7
作者：
Dunsmoor, Joseph E.;LaBar, Kevin S.
通讯作者：
LaBar, Kevin S.
影响因子：
--
作者：
BECK, AT;ERBAUGH, J;MENDELSOHN, M
通讯作者：
MENDELSOHN, M