Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson's disease.
Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson's disease.
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DOI：
10.1002/hbm.25745
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发表时间：
2022-04-01
影响因子：
4.8
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Wang L;Zhou C;Cheng W;Rolls ET;Huang P;Ma N;Liu Y;Zhang Y;Guan X;Guo T;Wu J;Gao T;Xuan M;Gu Q;Xu X;Zhang B;Gong W;Du J;Zhang W;Feng J;Zhang M
帕金森病（PD）的主要特征是皮质下区域的多巴胺能细胞的损失和萎缩。然而，这些病理变化对皮质大规模动态整合和分离的影响尚未得到很好的理解。在这项研究中，我们研究了皮质下功能障碍对帕金森病患者的皮质动力学和认知功能的影响。估计了159名PD患者和152名正常对照（NC）个体的静息状态血氧水平依赖性信号的相位相互作用的时空动力学。然后评估皮质下萎缩、皮质下-皮质纤维连接障碍、皮质同步化/亚稳定性和认知表现之间的关系。我们发现PD患者的皮层同步化和亚稳定性显著降低。为了研究这是否是多巴胺耗竭的影响，我们调查了45例PD患者，包括开和关多巴胺替代治疗，发现皮质同步和亚稳定性在开状态下显著增加。皮质同步化和亚稳态在OFF状态下的程度反映了认知性能，并介导了PD和NC组之间认知性能的差异。此外，丘脑体积和丘脑皮质纤维连接与多巴胺能OFF状态下的皮质同步化和亚稳定性呈正相关，并介导了PD和NC组之间皮质同步化的差异。此外，丘脑体积也反映了认知能力，皮质同步化/亚稳定性介导了PD患者丘脑体积与认知能力之间的关系。总之，这些结果强调了皮质下功能障碍和多巴胺水平降低是导致皮质同步和亚稳定性降低的原因，进一步影响了PD的认知表现。这可能导致生物标志物被识别，可以预测患者是否有患痴呆症的风险。提出了一种基于相位的皮层同步/亚稳定性分析，发现帕金森病（PD）的皮层同步和亚稳定性降低。左旋多巴使PD中降低的皮质同步化和亚稳定性正常化。皮层同步化和亚稳定性下降介导PD认知功能下降。丘脑体积和丘脑皮质纤维连接介导的同步性下降。
Parkinson's disease (PD) is primarily characterized by the loss of dopaminergic cells and atrophy in subcortical regions. However, the impact of these pathological changes on large‐scale dynamic integration and segregation of the cortex are not well understood. In this study, we investigated the effect of subcortical dysfunction on cortical dynamics and cognition in PD. Spatiotemporal dynamics of the phase interactions of resting‐state blood‐oxygen‐level‐dependent signals in 159 PD patients and 152 normal control (NC) individuals were estimated. The relationships between subcortical atrophy, subcortical–cortical fiber connectivity impairment, cortical synchronization/metastability, and cognitive performance were then assessed. We found that cortical synchronization and metastability in PD patients were significantly decreased. To examine whether this is an effect of dopamine depletion, we investigated 45 PD patients both ON and OFF dopamine replacement therapy, and found that cortical synchronization and metastability are significantly increased in the ON state. The extent of cortical synchronization and metastability in the OFF state reflected cognitive performance and mediates the difference in cognitive performance between the PD and NC groups. Furthermore, both the thalamic volume and thalamocortical fiber connectivity had positive relationships with cortical synchronization and metastability in the dopaminergic OFF state, and mediate the difference in cortical synchronization between the PD and NC groups. In addition, thalamic volume also reflected cognitive performance, and cortical synchronization/metastability mediated the relationship between thalamic volume and cognitive performance in PD patients. Together, these results highlight that subcortical dysfunction and reduced dopamine levels are responsible for decreased cortical synchronization and metastability, further affecting cognitive performance in PD. This might lead to biomarkers being identified that can predict if a patient is at risk of developing dementia. A phase‐based cortical synchronization/metastability analysis was proposed, and decreased cortical synchronization and metastability was found in Parkinson's disease (PD). Levodopa normalized the decreased cortical synchronization and metastability in PD. Cortical synchronization and metastability decline mediated cognitive decline of PD. Thalamus volume and thalamocortical fiber connectivity mediated synchronization decline.
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影响因子：
4.8
作者：
Gregory S;Long JD;Tabrizi SJ;Rees G
通讯作者：
Rees G
人脑网络组图谱：基于连接架构的新大脑图谱
DOI：
10.1093/cercor/bhw157
发表时间：
2016-08
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Fan L;Li H;Zhuo J;Zhang Y;Wang J;Chen L;Yang Z;Chu C;Xie S;Laird AR;Fox PT;Eickhoff SB;Yu C;Jiang T
通讯作者：
Jiang T
影响因子：
5.7
作者：
Alderson TH;Bokde ALW;Kelso JAS;Maguire L;Coyle D;Alzheimer's Disease Neuroimaging Initiative
通讯作者：
Alzheimer's Disease Neuroimaging Initiative
影响因子：
3.7
作者：
Gratton, Caterina;Koller, Jonathan M.;Campbell, Meghan C.
通讯作者：
Campbell, Meghan C.
影响因子：
4.8
作者：
Baggio, Hugo-Cesar;Sala-Llonch, Roser;Junque, Carme
通讯作者：
Junque, Carme