Cortical activity differs during nicotine deprivation versus satiation in heavy smokers.
Cortical activity differs during nicotine deprivation versus satiation in heavy smokers.
复制标题
在尼古丁剥夺期间，皮质活性与烟雾者的满足感有所不同。
DOI：
10.1007/s00213-014-3821-x
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发表时间：
2015-06
影响因子：
3.4
通讯作者：
Drobes, David J.
中科院分区：
文献类型：
--
作者：
Evans, David E.;Sutton, Steven K.;Oliver, Jason A.;Drobes, David J.
关键词：
研究表明，吸烟者的尼古丁剥夺与较低的静息皮层活动有关（即，脑电图θ和α -1波段的功率密度较高，而β波段的功率较低）。这些皮层活动的变化可能预示着戒断相关的认知缺陷，但皮层活动差异的标志尚未得到证实。为了弄清尼古丁剥夺对脑电图频带的影响并评估未来的调节作用，124名重度吸烟者在吸烟/尼古丁剥夺后两次访问了实验室。在收集三分钟静息脑电图数据之前，参与者在一个时段抽两支极低尼古丁香烟（尼古丁含量< 0.05毫克）和两支中等尼古丁香烟（尼古丁含量< 0.05毫克）。60毫克尼古丁产量)。在极低尼古丁（剥夺）条件下，相对于高尼古丁（满足）条件下，Theta和α -1波段（4-7和8-10 Hz）更大。β -1和β -2波段（14-20和21-30 Hz）无状态差异。更大的慢波静息脑电图可以作为吸烟剥夺期间皮层活动下降的可靠标志，反过来，戒断相关的认知功能缺陷。这项研究可能为戒烟辅助策略的发展提供信息。
Research suggests that nicotine deprivation among smokers is associated with lesser resting cortical activity (i.e., greater power density in theta and alpha-1 EEG bands and lesser power in beta bands). These changes in cortical activity may be indicative of withdrawal-related cognitive deficits, yet the markers of differences in cortical activity are not well-established. To clarify the EEG frequency bands affected by nicotine deprivation and assess prospective moderators 124 heavy smokers visited the laboratory on two occasions following overnight smoking/nicotine deprivation. Prior to collecting three minutes of resting EEG data, participants smoked two very low nicotine cigarettes (< .05 mg nicotine yield) at one session and two moderate nicotine cigarettes (.60 mg nicotine yield) at the other. Theta and alpha-1 band (4–7 & 8–10 Hz) was greater in the very low nicotine (deprivation) relative to higher nicotine (satiation) condition. There were no condition differences in the beta-1 and beta-2 bands (14–20 & 21–30 Hz). Greater slow wave resting EEG may serve as a reliable marker of decreased cortical activity during smoking deprivation and, in turn, of withdrawal-related deficits in cognitive functioning. This research may inform the development of adjunct strategies for smoking cessation.
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