The effect of symptom clusters on functional status and quality of life in women with breast cancer.
The effect of symptom clusters on functional status and quality of life in women with breast cancer.
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DOI：
10.1016/j.ejon.2009.09.005
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发表时间：
2010-04
影响因子：
2.8
通讯作者：
Miaskowski, Christine
中科院分区：
文献类型：
--
作者：
Dodd, Marylin J.;Cho, Maria H.;Cooper, Bruce A.;Miaskowski, Christine
关键词：
本研究的目的是对接受化疗伴/不伴放射治疗的乳腺癌妇女进行研究，以确定：1）肿瘤门诊患者的亚组是否可以根据特定的症状群（即，疼痛、疲劳、睡眠障碍、抑郁）; 2）这些亚组在结果上不同（即，功能状态、生活质量; 3）亚组成员随时间变化。二次数据分析使用的数据收集自112名妇女在初始化疗。在三个时间点完成症状和结果测量：基线（即，第二周期前一周-T1）;癌症治疗结束（T2），研究结束（化疗开始后约一年-T3）。聚类分析根据症状严重程度评分确定患者亚组。在T1和T2时，确定了四个患者亚组：ALL LOW（一个或没有症状大于切割评分），轻度（两个症状），中度（三个或四个症状）和ALL HIGH（四个症状）。在T3时，确定了三个亚组：轻度、中度和高度。所有四种症状严重程度高的亚组在每个时间点的功能状态和生活质量都比其他亚组差（p <0.001）。组成员随时间变化。确定了具有不同症状经历的患者亚组。对于一些患者，所有四种症状的严重程度在癌症治疗后持续数月。识别ALL HIGH患者亚组中患者的初始和持续评估非常重要，以便提供适当的干预措施来改善功能状态和生活质量。
The purposes of this study of women with breast cancer receiving chemotherapy with/without radiation therapy were to determine whether: 1) subgroups of oncology outpatients can be identified based on a specific symptom cluster (i.e., pain, fatigue, sleep disturbances, depression); 2) these subgroups differ on outcomes (i.e., functional status, quality of life; 3) subgroup membership changes over time. A secondary data analysis using data collected from 112 women at initial chemotherapy. Symptom and outcome measures were completed at three time points: baseline (i.e., the week before cycle two - T1); end of cancer treatment (T2), end of the study (approximately one year after the start of chemotherapy - T3). Cluster analysis identified patient subgroups based on symptom severity scores. At T1 and T2, four patient subgroups were identified: ALL LOW (one or no symptom greater than the cut score), MILD (two symptoms), MODERATE (three or four symptoms), and ALL HIGH (four symptoms). At T3, three subgroups were identified: MILD, MODERATE and ALL HIGH. Subgroups with high severity levels of all four symptoms had poorer functional status and QOL at each time point than other subgroups (p<.001). Group membership changed over time. Subgroups of patients with different symptom experiences were identified. For some patients severity of all four symptoms persisted months after cancer treatment. Initial and ongoing assessment to identify those patients in the ALL HIGH patient subgroup is important so that appropriate interventions to improve functional status and quality of life can be offered.
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影响因子：
8.8
作者：
Bianco, A R;Del Mastro, L;Gallo, C;Perrone, F;Matano, E;Pagliarulo, C;De Placido, S
通讯作者：
De Placido, S
DOI：
10.1046/j.1523-5394.1999.75008.x
发表时间：
1999-09-01
期刊：
CANCER PRACTICE
影响因子：
--
作者：
Gaston-Johansson, F;Fall-Dickson, JM;Kennedy, MJ
通讯作者：
Kennedy, MJ
影响因子：
1.9
作者：
Gift, AG;Jablonski, A;Given, CW
通讯作者：
Given, CW
影响因子：
3.1
作者：
Chen, Mei-Ling;Tseng, Ho-Ching
通讯作者：
Tseng, Ho-Ching
影响因子：
1.9
作者：
Byar, Katherine L;Berger, Ann M;Cetak, Melissa A
通讯作者：
Cetak, Melissa A