Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
Photosynthetic microorganisms coupled photodynamic therapy for enhanced antitumor immune effect.
复制标题
光合微生物联合光动力疗法增强抗肿瘤免疫效果。
DOI：
10.1016/j.bioactmat.2021.10.028
复制
发表时间：
2022-06
影响因子：
18.9
通讯作者：
Wu J
中科院分区：
文献类型：
--
作者：
Wang H;Liu H;Guo Y;Zai W;Li X;Xiong W;Zhao X;Yao Y;Hu Y;Zou Z;Wu J
理想的光动力学治疗（PDT）应能有效切除原发肿瘤，并产生较强的免疫记忆效应，抑制肿瘤复发和转移。然而，受缺氧和免疫抑制微环境的限制，PDT的效率明显较低。这里，小球藻（Chl.）通过产生氧气来逆转缺氧，并释放佐剂来逆转免疫抑制微环境，从而增强远端效应。不同动物模型的结果表明，Chl.能增强局部效应和PDT相关的免疫应答。最后，Chl。结果表明，PDT对原发性肿瘤和远端肿瘤的抑制率分别为90%和75%，对攻击性肿瘤的抑制率为100%，对转移性肿瘤的抑制率为90%。这个Chl.联合PDT策略也能产生较强的抗肿瘤免疫记忆效应。总的来说，这个Chl。联合PDT策略可增强局部肿瘤杀伤，增强PDT诱导的免疫应答，促进抗肿瘤免疫记忆效应，这可能是PDT实现全身效应的一大进展。小球藻在光照射下可作为氧供应者并释放佐剂以增强光动力学治疗（PDT）。小球藻的双重特性加强了有效抗肿瘤免疫反应的发生。小球藻具有良好的生物相容性，可增强局部和远侧抗肿瘤作用。
The ideal photodynamic therapy (PDT) should effectively remove the primary tumor, and produce a stronger immune memory effect to inhibit the tumor recurrence and tumor metastasis. However, limited by the hypoxic and immunosuppressive microenvironment, the PDT efficiency is apparently low. Here, Chlorella (Chl.) is exploited to enhance local effect by producing oxygen to reverse hypoxia, and release adjuvants to reverse immunosuppressive microenvironment to enhance abscopal effect afterwards. Results from different animal models indicated that Chl. could enhance local effect and PDT related immune response. Ultimately, Chl. coupled PDT elicited anti-tumor effects toward established primary tumors (inhibition rate: 90%) and abscopal tumors (75%), controlled the challenged tumors (100%) and alleviated metastatic tumors (90%). This Chl. coupled PDT strategy can also produce a stronger anti-tumor immune memory effect. Overall, this Chl. coupled PDT strategy generates enhanced local tumor killing, boosts PDT-induced immune responses and promotes anti-tumor immune memory effect, which may be a great progress for realizing systemic effect of PDT. Chlorella can act as oxygen supplier and release adjuvants under light irradiation to enhance photodynamic therapy (PDT). The dual characteristics of Chlorella strengthen the occurrence of effective anti-tumor immune responses. Enhanced local and abscopal anti-tumor effect can be achieved by Chlorella with good biocompatibility.
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DOI：
10.1038/nrc3258
发表时间：
2012-03-22
期刊：
Nature reviews. Cancer
影响因子：
--
作者：
通讯作者：
--
影响因子：
30.5
作者：
Fukao, T;Tanabe, M;Koyasu, S
通讯作者：
Koyasu, S
DOI：
10.1155/2012/735396
发表时间：
2012
期刊：
Evidence-based complementary and alternative medicine : eCAM
影响因子：
--
作者：
Chou NT;Cheng CF;Wu HC;Lai CP;Lin LT;Pan IH;Ko CH
通讯作者：
Ko CH
影响因子：
5.6
作者：
Hasegawa, T;Matsuguchi, T;Yoshikai, Y
通讯作者：
Yoshikai, Y
影响因子：
16.6
作者：
Chen, Minhui;Qiao, Guanxi;Repasky, Elizabeth A.
通讯作者：
Repasky, Elizabeth A.