Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders.

Implications of Oxidative Stress in the Pathogenesis and Treatment of Hyperpigmentation Disorders.
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氧化应激对色素沉着过度疾病发病机制和治疗的影响

DOI:
10.1155/2022/7881717
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发表时间:
2022
影响因子:
--
通讯作者:
Xiang L
Xiang L
中科院分区:
生物学2区
文献类型:
--
作者:
Xing X;Dan Y;Xu Z;Xiang L

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氧化应激表现为活性氧和氮的生成与抗氧化系统分解这些产物的能力之间的不平衡。氧化应激与色素沉着、色素沉着、黑色素瘤和其他皮肤病的发病机制有关。涉及氧化应激和相关途径的调控网络在色素沉着性疾病,特别是白癜风中广泛存在。然而,对于氧化应激在色素沉着症发病机制中的作用,特别是氧化应激与细胞信号通路的关系,目前还没有完整的综述。在这里,我们回顾氧化和抗氧化系统,氧化应激诱导的信号转导机制,以及抗氧化药物在临床前和临床环境中对色素沉着症的影响。
Oxidative stress represents an imbalance between the generation of reactive oxygen and nitrogen species and the ability of antioxidant systems to decompose those products. Oxidative stress is implicated in the pathogenesis of hyperpigmentation, hypopigmentation, melanoma, and other skin diseases. Regulatory networks involving oxidative stress and related pathways are widely represented in hypopigmentation diseases, particularly vitiligo. However, there is no complete review into the role of oxidative stress in the pathogenesis of hyperpigmentation disorders, especially regarding associations involving oxidative stress and cellular signaling pathways. Here, we review oxidative and antioxidant systems, oxidative stress-induced signal transduction mechanisms, and effects of antioxidant drugs used in preclinical and clinical settings in hyperpigmentation disorders.
DOI: 10.1207/s15327914nc381_13
发表时间: 2000-01-01
影响因子: 2.9
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