The Expression of LIGHT Was Increased and the Expression of HVEM and BTLA Were Decreased in the T Cells of Patients with Rheumatoid Arthritis
The Expression of LIGHT Was Increased and the Expression of HVEM and BTLA Were Decreased in the T Cells of Patients with Rheumatoid Arthritis
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类风湿性关节炎患者T细胞中LIGHT表达增加，HVEM和BTLA表达减少
DOI：
10.1371/journal.pone.0155345
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发表时间：
2016-05
期刊：
影响因子：
3.7
通讯作者：
Wang, Lanlan
中科院分区：
文献类型：
--
作者：
Wu, Zhiqiang;Cai, Bei;Bai, Yangjuan;Wang, Lanlan
Background Currently, the pathogenesis of rheumatoid arthritis (RA) is not clearly understood. The LIGHT/HVEM/BTLA co-signaling pathway may be involved in the pathogenesis of RA, although reports on the expression levels of LIGHT, HVEM and BTLA in T lymphocytes from RA patients are limited. Method In this study, we recruited 30 healthy controls and 21 RA patients. Clinical characteristics were collected for RA patients. The levels of LIGHT, HVEM and BTLA expressed on the surface of circulating T cells of RA patients and healthy controls were measured by flow cytometry. Result The percentages of CD3+, CD4+ and CD8+ T lymphocytes that expressed BTLA from RA patients were all higher than those of the controls (all p < 0.05), while the percentages of CD3+, CD4+ and CD8+ T lymphocytes that expressed HVEM and LIGHT were all lower than those of the controls (all p < 0.05). The rheumatoid factor and the percentage of HVEM+CD4+ T lymphocytes showed a statistically significant negative correlation in RA patients (r = -0.453, p = 0.039), as did the swollen joint count and the percentage of BTLA+CD8+ T lymphocytes (r = -0.501, p = 0.021). Conclusion Here, we provide the first report on the increased expression of BTLA in T lymphocytes and on the decreased expression of HVEM and LIGHT in RA patients. BTLA, HVEM and LIGHT might be involved in the pathogenesis of RA and have the potential to be new clinically useful characteristics of RA.
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影响因子：
7
作者：
Ware CF;Sedý JR
通讯作者：
Sedý JR
影响因子：
--
作者：
Oki M;Watanabe N;Owada T;Oya Y;Ikeda K;Saito Y;Matsumura R;Seto Y;Iwamoto I;Nakajima H
通讯作者：
Nakajima H
DOI：
10.1073/pnas.0902115106
发表时间：
2009-04-14
影响因子：
11.1
作者：
Cheung, Timothy C.;Steinberg, Marcos W.;Ware, Carl F.
通讯作者：
Ware, Carl F.
影响因子：
--
作者：
Oya, Yoshihiro;Watanabe, Norihiko;Owada, Takayoshi;Oki, Mie;Hirose, Koichi;Suto, Akira;Kagami, Shin-ichiro;Nakajima, Hiroshi;Kishimoto, Takashi;Iwamoto, Itsuo;Murphy, Theresa L.;Murphy, Kenneth M.;Saito, Yasushi
通讯作者：
Saito, Yasushi
BTLA及其配体HVEM在类风湿滑膜中的表达和解剖分布
影响因子：
5.1
作者：
Shang, Yongjun;Guo, Guoning;Cui, Qifu;Li, Jinlong;Ruan, Zhihua;Chen, Yongwen
通讯作者：
Chen, Yongwen