Evidence-based guidelines for interpretation of the Panic Disorder Severity Scale.
Evidence-based guidelines for interpretation of the Panic Disorder Severity Scale.
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基于证据的恐慌症严重程度量表的指南。
DOI：
10.1002/da.20532
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发表时间：
2009
影响因子：
7.4
通讯作者：
Leucht, Stefan
中科院分区：
文献类型：
--
作者：
Furukawa, Toshi A.;Shear, M. Katherine;Barlow, David H.;Gorman, Jack M.;Woods, Scott W.;Money, Roy;Etschel, Eva;Engel, Rolf R.;Leucht, Stefan
关键词：
惊恐障碍严重程度量表（PDSS）有望成为惊恐障碍的标准全球评级量表。为了使临床量表有用，我们需要一个指南来解释其评分及其变化，并定义临床变化点，如反应和缓解。我们使用了来自两项大型随机对照试验的惊恐障碍患者个体数据（共n=568）。研究参与者被给予PDSS和临床总体印象（CGI）-严重程度和-改善。我们应用等百分位数链接技术绘制PDSS和CGI-严重程度、PDSS和CGI-改善的数值变化以及PDSS和CGI-改善的百分比变化之间的对应关系。PDSS总分的解释根据广场恐怖症的存在或不存在而不同。当患者没有广场恐怖症时，评分范围0-1对应于“正常”，2-5对应于“边缘”，6-9对应于“轻微疾病”，10-13对应于“中度疾病”，14及以上对应于“明显疾病”。当患者患有广场恐怖症时，评分范围3-7表示“边缘病”，8-10表示“轻微病”，11-15表示“中度病”，16及以上表示“明显病”。PDSS变化和CGI改善之间的关系是更线性的百分位数的变化比数字的变化，并与广场恐怖症或无区分。下降75-100%被视为“非常改善”，下降40-74%被视为“显著改善”，下降10-39%被视为“轻微改善”。我们建议惊恐障碍的“缓解”定义为PDSS评分为5分或更低，其“反应”定义为40%或更高的减少。
The Panic Disorder Severity Scale (PDSS) is promising to be a standard global rating scale for panic disorder. In order for a clinical scale to be useful, we need a guideline for interpreting its scores and their changes, and for defining clinical change points such as response and remission. We used individual patient data from two large randomized controlled trials of panic disorder (total n=568). Study participants were administered the PDSS and the Clinical Global Impression (CGI)-Severity and -Improvement. We applied equipercentile linking technique to draw correspondences between PDSS and CGI-Severity, numeric changes in PDSS and CGI-Improvement, and percent changes in PDSS and CGI-Improvement. The interpretation of the PDSS total score differed according to the presence or absence of agoraphobia. When the patients were not agoraphobic, score ranges 0–1 corresponded with “Normal,” 2–5 with “Borderline”, 6–9 with “Slightly ill”, 10–13 with “Moderately ill”, and 14 and above with “Markedly ill.” When the patients were agoraphobic, score ranges 3–7 meant “Borderline ill,” 8–10 “Slightly ill,” 11–15 “Moderately ill,” and 16 and above “Markedly ill.” The relationship between PDSS change and CGI-Improvement was more linear when measured as percentile change than as numeric changes, and was indistinguishable for those with or without agoraphobia. The decrease by 75–100% was considered “Very much improved,” that by 40–74% “Much improved,” and that by 10–39% “Minimally improved.” We propose that “remission” of panic disorder be defined by PDSS scores of 5 or less and its “response” by 40% or greater reduction.
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影响因子：
7.4
作者：
Lim, Young-Jin;Yu, Bum-Hee;Kim, Ji-Hae
通讯作者：
Kim, Ji-Hae
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