Randomised study of adjuvant chemotherapy for completely resected p-stage I-IIIA non-small cell lung cancer.
Randomised study of adjuvant chemotherapy for completely resected p-stage I-IIIA non-small cell lung cancer.
复制标题
DOI：
10.1038/sj.bjc.6603336
复制
发表时间：
2006-10-09
影响因子：
8.8
通讯作者：
Kodama, K.
中科院分区：
文献类型：
--
作者：
Nakagawa, K.;Tada, H.;Akashi, A.;Yasumitsu, T.;Iuchi, K.;Taki, T.;Kodama, K.
关键词：
我们评估了辅助化疗在完全切除的非小细胞肺癌（NSCLC）患者中的治疗作用。我们还研究了DNA倍体模式与化疗反应之间的关系。共有267例非小细胞肺癌患者（病理记录为I、II或IIIA期）接受了完全切除，并分析了DNA倍体模式。I期疾病患者（n=172）被随机分配接受单独手术（A组）或手术后辅助化疗(UFT（口服抗癌药物，联合尿嘧啶和泰加富）400 mg，术后1年；B组)。II期或IIIA期疾病患者（n=95）被随机分配到单独手术（C组）或手术后化疗（2个28天疗程，顺铂80mg m−2，第1天和第8天，长春地辛3mg m−2，随后UFT 400mg天−1，至少1年；D组）。B组I期患者的8年总生存率为74.2%(95%可信区间（CI）： 64.4-84.0%)， A组为57.6% (95% CI: 46.4-68.8%) （log-rank检验P=0.045）。在II期和IIIA期患者中，C组和d组之间没有差异。根据DNA倍体模式分析，两组之间没有差异。UFT术后化疗被认为对完全切除的I期非小细胞肺癌患者有用。在任何治疗组中都没有发现DNA模式的差异。
We evaluated the therapeutic usefulness of adjuvant chemotherapy in patients with completely resected non-small cell lung cancer (NSCLC). We also examined the relation between DNA ploidy pattern and the response to chemotherapy. A total of 267 patients with NSCLC (pathologically documented stage I, II, or IIIA) underwent complete resection, and DNA ploidy pattern was analysed. Patients with stage I disease (n=172) were randomly assigned to receive surgery alone (group A) or surgery followed by adjuvant chemotherapy (UFT (oral anti-cancer drug, a combination of Uracil and Tegaful) 400 mg day−1 for 1 year after surgery; group B). Stage II or IIIA disease patients (n=95) were randomly assigned to surgery alone (group C) or surgery followed by chemotherapy (two 28-day courses of cisplatin 80 mg m−2 on day 1 plus vindesine 3 mg m−2 on days 1 and 8, followed by UFT 400 mg day−1 for at least 1 year; group D). Eight-year overall survival rate in patients with stage I disease was 74.2% (95% confidence interval (CI): 64.4–84.0%) in group B and 57.6% (95% CI: 46.4–68.8%) in group A (P=0.045 by log-rank test). In patients with stage II and IIIA disease, no difference was found between groups C and D. Analysis according to DNA ploidy pattern revealed no difference between the groups. Postoperative chemotherapy with UFT was suggested to be useful in patients with completely resected stage I NSCLC. No difference was seen in relation to DNA pattern in any treatment group.
登录
查看更多内容
影响因子：
10.3
作者：
Scagliotti, GV;Fossati, R;Tonato, M
通讯作者：
Tonato, M
影响因子：
8.8
作者：
Peto R;Pike MC;Armitage P;Breslow NE;Cox DR;Howard SV;Mantel N;McPherson K;Peto J;Smith PG
通讯作者：
Smith PG
影响因子：
2.4
作者：
KEICHO, N;SAIJO, N;HOSHI, A
通讯作者：
HOSHI, A
影响因子：
9.8
作者：
Basaki, Yuji;Chikahisa, Lumi;Yamada, Yuji
通讯作者：
Yamada, Yuji
影响因子：
3.6
作者：
SALVATI, F;TEODORI, L;GOHDE, W
通讯作者：
GOHDE, W