The Mechanism by Which Dodecyl Dimethyl Benzyl Ammonium Chloride Increased the Toxicity of Chlorpyrifos to Spodoptera exigua.
The Mechanism by Which Dodecyl Dimethyl Benzyl Ammonium Chloride Increased the Toxicity of Chlorpyrifos to Spodoptera exigua.
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十二烷基二甲基苄基氯化铵增加毒死蜱对甜菜夜蛾毒性的机制
DOI：
10.3389/fphar.2017.00475
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发表时间：
2017
影响因子：
5.6
通讯作者：
Mu W
中科院分区：
文献类型：
--
作者：
Cui L;Yuan H;Yang D;Rui C;Mu W
甜菜夜蛾（Spodoptera exigua（Hübner））是一种严重危害农作物的害虫。不幸的是，S.甜菜对大多数杀虫剂产生了抗药性。增效剂可能为解决植物的抗药性问题提供一个重要的选择。十二烷基二甲基苄基氯化铵（DDBAC）是一种阳离子表面活性剂，与毒死蜱复配后，对毒死蜱的杀灭效果有增效作用。甜菜，在90和810 mg L−1浓度下的增强因子分别为1.50和1.57。为了阐明可能的机制，我们研究了DDBAC对解毒酶的影响。DDBAC对上述酶活性无抑制作用。同时，扫描电镜观察表明DDBAC对S. exigua.角质层渗透率的变化也被观察到，事实上，它已经表明，增效作用是通过加速杀虫剂渗透通过角质层。当与90和810 mg L−1 DDBAC结合时，毒死蜱渗透率急剧增加，8 h后通过外部冲洗仅恢复了初始毒死蜱的12.6%和8.5%。相比之下，当没有DDBAC时，在8小时后恢复超过初始剂量的23.3%。
Beet armyworm, Spodoptera exigua (Hübner) is one of the most destructive pests that causes significant losses in crops. Unfortunately, S. exigua have developed resistance toward the majority of insecticides. Synergists may provide an important choice to deal with the resistance problems. Dodecyl dimethyl benzyl ammonium chloride (DDBAC) is a cationic surfactant, which displayed enhancement effect when combined with chlorpyrifos against S. exigua, giving enhancement factors of 1.50 and 1.57 at the concentrations of 90 and 810 mg L−1. In order to clarify the possible mechanisms, we investigate the effects of DDBAC on detoxification enzymes. However, DDBAC showed no inhibition on these enzymes activities. Meanwhile, scanning electron microscope images indicated DDBAC did not affect the cuticle super micro structure of S. exigua. The alterations in cuticular penetration rate have also been observed; indeed, it has been suggested that synergism is obtained by an acceleration of insecticide penetration through the cuticle. The chlorpyrifos penetration increased sharply when combined with 90 and 810 mg L−1 DDBAC, with only 12.6 and 8.5% of the initial chlorpyrifos recovered by external rinsing after 8 h. In contrast, when there was no DDBAC, more than 23.3% of the initial dose was recovered after 8 h.
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影响因子：
5.8
作者：
ELLMAN, GL;COURTNEY, KD;FEATHERSTONE, RM
通讯作者：
FEATHERSTONE, RM
影响因子：
2.8
作者：
Ahmad, Mushtaq;Arif, M. Iqbal
通讯作者：
Arif, M. Iqbal
影响因子：
2.8
作者：
Ishtiaq, M.;Salem, Mushtaq A.;Razaq, M.
通讯作者：
Razaq, M.
影响因子：
4.1
作者：
Smagghe, G;Pineda, S;Viñuela, E
通讯作者：
Viñuela, E
影响因子：
5.8
作者：
HANSEN, LG;HODGSON, E
通讯作者：
HODGSON, E