The aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism.
The aryl hydrocarbon receptor (AhR) pathway as a regulatory pathway for cell adhesion and matrix metabolism.
复制标题
DOI：
10.1016/j.bcp.2008.09.031
复制
发表时间：
2009-02-15
影响因子：
5.8
通讯作者：
White LA
中科院分区：
文献类型：
--
作者：
Kung T;Murphy KA;White LA
芳香烃受体（aryl hydrocarbon receptor，AhR）是转录调节因子PAS家族中的一种孤儿受体。尽管该途径的内源性调节因子尚未确定，但已知AhR可以结合从环境污染物到黄酮类化合物等多种化合物并被其激活。这种受体的功能尚不清楚;然而，动物模型表明AhR对正常发育很重要。一种假设是AhR感知细胞应激并通过改变基因表达和抑制细胞周期进程来启动细胞应答，并且外源性环境化学物质对AhR的激活导致这种正常功能的失调。在这篇综述中，我们将研究的AhR的基因和蛋白参与细胞粘附和基质重塑的调节中的作用，并讨论这些变化在发展和疾病的影响。此外，我们将讨论的证据表明，AhR途径是响应矩阵组成的变化，以及细胞-细胞和细胞-基质相互作用。
The aryl hydrocarbon receptor (AhR) is an orphan receptor in the basic-helix-loop-helix PAS family of transcriptional regulators. Although the endogenous regulator of this pathway has not been identified, the AhR is known to bind and be activated by a variety of compounds ranging from environmental contaminants to flavanoids. The function of this receptor is still unclear; however, animal models indicate that the AhR is important for normal development. One hypothesis is that the AhR senses cellular stress and initiates the cellular response by altering gene expression and inhibiting cell cycle progression and that activation of the AhR by exogenous environmental chemicals results in the dysregulation of this normal function. In this review we will examine the role of the AhR in the regulation of genes and proteins involved in cell adhesion and matrix remodeling, and discuss the implications of these changes in development and disease. In addition, we will discuss evidence suggesting that the AhR pathway is responsive to changes in matrix composition as well as cell-cell and cell-matrix interactions.
登录
查看更多内容
影响因子：
2.7
作者：
Fata, JE;Leco, KJ;Khokha, R
通讯作者：
Khokha, R
影响因子：
10.4
作者：
BROWN, NM;LAMARTINIERE, CA
通讯作者：
LAMARTINIERE, CA
影响因子：
3.8
作者：
Flaws, JA;Sommer, RJ;Hirshfield, AN
通讯作者：
Hirshfield, AN
影响因子：
4.4
作者：
Abe, Yumiko;Sinozaki, Hiromitsu;Miyamoto, Kaoru
通讯作者：
Miyamoto, Kaoru
影响因子：
3.8
作者：
Antkiewicz, DS;Burns, CG;Heideman, W
通讯作者：
Heideman, W