Estimation of the burden of active and life-time epilepsy: a meta-analytic approach.
Estimation of the burden of active and life-time epilepsy: a meta-analytic approach.
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DOI：
10.1111/j.1528-1167.2009.02481.x
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发表时间：
2010-05
期刊：
影响因子：
5.6
通讯作者：
Newton CR
中科院分区：
文献类型：
--
作者：
Ngugi AK;Bottomley C;Kleinschmidt I;Sander JW;Newton CR
估计终生癫痫 (LTE) 和活动性癫痫 (AE) 的负担，并检查研究特征对患病率估计的影响。我们搜索在线数据库并使用预先指定的标准识别文章。使用随机效应荟萃分析来估计发达国家以及发展中国家城乡环境中的中位患病率。使用元回归模型确定研究特征对患病率估计的影响。发达国家的 LTE 普及率中位数为每 1,000 人 5.8 人（第 5-95 百分位数范围 2.7-12.4），而发展中国家农村地区的 LTE 普及率中位数为每 1,000 人 15.4 人（4.8-49.6），城市研究为每 1,000 人 10.3 人（2.8-37.7）。发达国家的 AE 患病率中位数为每 1,000 人 4.9 例 (2.3–10.3)，而在发展中国家的农村和城市研究中，AE 患病率中位数为每 1,000 人 12.7 例 (3.5–45.5) 和 5.9 例 (3.4–10.2)。发达国家 LTE 和 AE 的负担估计分别为 680 万（第 5-95 个百分位数范围 3.2-14.7）和 570 万（2.7-12.2）。在发展中国家，农村地区有 45 (14-145) 百万 LTE 和 17 (10-133) 百万 AE，城市地区有 17 (5-61) 百万 LTE 和 10 (5-17) 百万 AE。涉及所有年龄段或仅成人的研究显示出比儿科研究更高的估计值。较高的患病率估计值也与农村地区和较小的研究规模有关。这项研究估计了癫痫的全球负担以及可能受益于治疗的 AE 比例。报告的患病率估计值存在系统性差异，研究特征只能部分解释这一差异。
To estimate the burden of lifetime epilepsy (LTE) and active epilepsy (AE) and examine the influence of study characteristics on prevalence estimates. We searched online databases and identified articles using prespecified criteria. Random-effects meta-analyses were used to estimate the median prevalence in developed countries and in urban and rural settings in developing countries. The impact of study characteristics on prevalence estimates was determined using meta-regression models. The median LTE prevalence for developed countries was 5.8 per 1,000 (5th–95th percentile range 2.7–12.4) compared to 15.4 per 1,000 (4.8–49.6) for rural and 10.3 (2.8–37.7) for urban studies in developing countries. The median prevalence of AE was 4.9 per 1,000 (2.3–10.3) for developed countries and 12.7 per 1,000 (3.5–45.5) and 5.9 (3.4–10.2) in rural and urban studies in developing countries. The estimates of burden for LTE and AE in developed countries were 6.8 million (5th–95th percentile range 3.2–14.7) and 5.7 million (2.7–12.2), respectively. In developing countries these were 45 (14–145) million LTE and 17 (10–133) million AE in rural areas and 17 (5–61) million LTE and 10 (5–17) million AE in urban areas. Studies involving all ages or only adults showed higher estimates than pediatric studies. Higher prevalence estimates were also associated with rural location and small study size. This study estimates the global burden of epilepsy and the proportions with AE, which may benefit from treatment. There are systematic differences in reported prevalence estimates, which are only partially explained by study characteristics.
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影响因子：
5.6
作者：
Diop, AG;Hesdorffer, DC;Hauser, WA
通讯作者：
Hauser, WA
影响因子：
5.6
作者：
Annegers, JF;Dubinsky, S;Roht, L
通讯作者：
Roht, L
影响因子：
5.6
作者：
Holden, EW;Nguyen, HT;Thurman, DJ
通讯作者：
Thurman, DJ
DOI：
10.1016/0197-2456(89)90030-5
发表时间：
1989-06-01
期刊：
CONTROLLED CLINICAL TRIALS
影响因子：
--
作者：
GOODMAN, SN
通讯作者：
GOODMAN, SN
影响因子：
5.6
作者：
GRACIA, F;DELAO, SL;REEVES, WC
通讯作者：
REEVES, WC